(E)-ethyl 2-(tetrahydro-1H-pyrrolizin-3(6H)-ylidene)-3-(m-tolyl)-3-oxopropanoate

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Chemical Name:(E)-ethyl 2-(tetrahydro-1H-pyrrolizin-3(6H)-ylidene)-3-(m-tolyl)-3-oxopropanoate
CAS No.:1417036-71-5
Molecular Formula:C₁₉H₂₃NO₃
Molecular Weight:313.397
Hs Code.:

Synonyms:(E)-ethyl 2-(tetrahydro-1H-pyrrolizin-3(6H)-ylidene)-3-(m-tolyl)-3-oxopropanoate

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Chemical Property of (E)-ethyl 2-(tetrahydro-1H-pyrrolizin-3(6H)-ylidene)-3-(m-tolyl)-3-oxopropanoate

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Technology Process of (E)-ethyl 2-(tetrahydro-1H-pyrrolizin-3(6H)-ylidene)-3-(m-tolyl)-3-oxopropanoate

There total 4 articles about (E)-ethyl 2-(tetrahydro-1H-pyrrolizin-3(6H)-ylidene)-3-(m-tolyl)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₃₃NO₆

: 1417036-71-5
(E)-ethyl 2-(tetrahydro-1H-pyrrolizin-3(6H)-ylidene)-3-(m-tolyl)-3-oxopropanoate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; water; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tet.2012.11.029

Reference yield:

: 1417036-60-2
tert-butyl 2-(4-(ethoxycarbonyl)-3-oxobutyl)pyrrolidine-1-carboxylate

: 1417036-71-5
(E)-ethyl 2-(tetrahydro-1H-pyrrolizin-3(6H)-ylidene)-3-(m-tolyl)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium chloride; pyridine / dichloromethane / 0.83 h / 5 °C / Inert atmosphere

1.2: 5.2 h / 5 - 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C / Inert atmosphere

With pyridine; trifluoroacetic acid; magnesium chloride; In dichloromethane; water;
DOI:10.1016/j.tet.2012.11.029

Reference yield:

: tert-butyl 2-((E)-4-(ethoxycarbonyl)-3-oxobut-1-enyl)pyrrolidine-1-carboxylate

: 1417036-71-5
(E)-ethyl 2-(tetrahydro-1H-pyrrolizin-3(6H)-ylidene)-3-(m-tolyl)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol / 2 h / 20 °C / 2068.65 Torr

2.1: magnesium chloride; pyridine / dichloromethane / 0.83 h / 5 °C / Inert atmosphere

2.2: 5.2 h / 5 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; magnesium chloride; In ethanol; dichloromethane; water;
DOI:10.1016/j.tet.2012.11.029