(1R,2R)-N-(cyanomethyl)-2-((R)-2-methyl-4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide

Base Information

Chemical Name:(1R,2R)-N-(cyanomethyl)-2-((R)-2-methyl-4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide
CAS No.:1403499-39-7
Molecular Formula:C₂₁H₂₈N₄O₂
Molecular Weight:368.479
Hs Code.:

Synonyms:(1R,2R)-N-(cyanomethyl)-2-((R)-2-methyl-4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide

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Chemical Property of (1R,2R)-N-(cyanomethyl)-2-((R)-2-methyl-4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide

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Technology Process of (1R,2R)-N-(cyanomethyl)-2-((R)-2-methyl-4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide

There total 4 articles about (1R,2R)-N-(cyanomethyl)-2-((R)-2-methyl-4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 85-42-7,13149-00-3,14166-21-3,31982-85-1,71749-03-6,97233-90-4
trans-1,2-cyclohexanedicarboxylic anhydride

: 1095542-54-3
(R)-3-methyl-1-phenylpiperazine

: 6011-14-9
2-aminoacetonitrile hydrochloride

: 1403499-39-7
(1R,2R)-N-(cyanomethyl)-2-((R)-2-methyl-4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide

Guidance literature:: trans-1,2-cyclohexanedicarboxylic anhydride; (R)-3-methyl-1-phenylpiperazine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

2-aminoacetonitrile hydrochloride; With HATU; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/jm301119s

Reference yield:

: 1403499-53-5
(R)-tert-butyl-2-methyl-4-phenylpiperazine-1-carboxylate

: 1403499-39-7
(1R,2R)-N-(cyanomethyl)-2-((R)-2-methyl-4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / methanol / 16 h / 25 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 20 °C

2.2: 16 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm301119s

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 1403499-39-7
(1R,2R)-N-(cyanomethyl)-2-((R)-2-methyl-4-phenylpiperazine-1-carbonyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium diacetate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; sodium t-butanolate / N,N-dimethyl-formamide / 16 h / Inert atmosphere; Reflux

2.1: hydrogenchloride / methanol / 16 h / 25 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 20 °C

3.2: 16 h / 20 °C

With hydrogenchloride; palladium diacetate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm301119s