5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine

Base Information

Chemical Name:5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine
CAS No.:1363287-12-0
Molecular Formula:C₂₁H₂₂N₂OS
Molecular Weight:350.484
Hs Code.:

Synonyms:5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine

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Chemical Property of 5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine

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Technology Process of 5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine

There total 5 articles about 5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1363287-07-3
5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepin-4-one

: 1363287-12-0
5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine

Guidance literature:: 5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepin-4-one; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran;

Reference yield:

: 1312415-24-9
3-bromodihydro-1-[(4-methoxyphenyl)methyl]-1H-azepine-2,4(3H,5H)-dione

: 1363287-12-0
5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 0.5 h / 100 °C

2.1: water; ammonium cerium (IV) nitrate / acetonitrile / 16 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oils / 1 h / 0 - 20 °C

3.2: 16 h / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; ammonium cerium (IV) nitrate; water; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; mineral oils;

Reference yield:

: 1312415-25-0
5,6,7,8-tetrahydro-5-[(4-methoxyphenyl)methyl]-2-(phenoxymethyl)-4H-thiazolo[5,4-c]azepin-4-one

: 1363287-12-0
5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; ammonium cerium (IV) nitrate / acetonitrile / 16 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oils / 1 h / 0 - 20 °C

2.2: 16 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; ammonium cerium (IV) nitrate; water; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; mineral oils;