5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine

Base Information

• Chemical Name: 5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine
• CAS No.: 1363287-12-0
• Molecular Formula: C₂₁H₂₂N₂OS
• Molecular Weight: 350.484
• Mol file: 1363287-12-0.mol

Synonyms:5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine

Chemical Property of 5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine

There total 5 articles about 5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepin-4-one (1363287-07-3) → 5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine (1363287-12-0)

Guidance literature:

5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepin-4-one; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran;

Reference yield:

3-bromodihydro-1-[(4-methoxyphenyl)methyl]-1H-azepine-2,4(3H,5H)-dione (1312415-24-9) → 5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine (1363287-12-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 0.5 h / 100 °C

2.1: water; ammonium cerium (IV) nitrate / acetonitrile / 16 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oils / 1 h / 0 - 20 °C

3.2: 16 h / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; ammonium cerium (IV) nitrate; water; sodium hydride; sodium hydrogencarbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; mineral oils;

Reference yield:

5,6,7,8-tetrahydro-5-[(4-methoxyphenyl)methyl]-2-(phenoxymethyl)-4H-thiazolo[5,4-c]azepin-4-one (1312415-25-0) → 5,6,7,8-tetrahydro-2-(phenoxymethyl)-5-(phenylmethyl)-4H-thiazolo[5,4-c]azepine (1363287-12-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water; ammonium cerium (IV) nitrate / acetonitrile / 16 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oils / 1 h / 0 - 20 °C

2.2: 16 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; ammonium cerium (IV) nitrate; water; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; mineral oils;

upstream raw materials:

N-(p-methoxybenzyl)azepane-2,4-dione

3-bromodihydro-1-[(4-methoxyphenyl)methyl]-1H-azepine-2,4(3H,5H)-dione

5,6,7,8-tetrahydro-5-[(4-methoxyphenyl)methyl]-2-(phenoxymethyl)-4H-thiazolo[5,4-c]azepin-4-one

5,6,7,8-tetrahydro-2-(phenoxymethyl)-4H-thiazolo[5,4-c]azepin-4-one

Downstream raw materials:

5,6,7,8-tetrahydro-2-(phenoxymethyl)-4H-thiazolo[5,4-c]azepine