C₂₈H₄₄N₄O

Base Information

Chemical Name:C₂₈H₄₄N₄O
CAS No.:1519003-88-3
Molecular Formula:C₂₈H₄₄N₄O
Molecular Weight:452.684
Hs Code.:

C<sub>28</sub>H<sub>44</sub>N<sub>4</sub>O

Synonyms:C₂₈H₄₄N₄O

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Chemical Property of C₂₈H₄₄N₄O

Chemical Property:

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Technology Process of C₂₈H₄₄N₄O

There total 7 articles about C₂₈H₄₄N₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76272-34-9
8-Benzyl-1αH,5αH-nortropan-3-one Oxime

: 1519003-88-3
C₂₈H₄₄N₄O

Guidance literature:: Multi-step reaction with 7 steps

1: sodium; propan-1-ol / toluene / 12 h / Reflux; Inert atmosphere

2: tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

3: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5: phosphorus pentachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

6: dichloromethane; tert-Amyl alcohol / 0 - 20 °C / Inert atmosphere

7: acetic acid / ethyl acetate / 0.5 h / 80 °C / Inert atmosphere

With hydrogenchloride; propan-1-ol; phosphorus pentachloride; sodium; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; tert-Amyl alcohol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ml400370w

Reference yield:

: 8-benzyl-8-azabicyclo[3.2.1]octan-3-amine

: 1519003-88-3
C₂₈H₄₄N₄O

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

2: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: phosphorus pentachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

5: dichloromethane; tert-Amyl alcohol / 0 - 20 °C / Inert atmosphere

6: acetic acid / ethyl acetate / 0.5 h / 80 °C / Inert atmosphere

With hydrogenchloride; phosphorus pentachloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; tert-Amyl alcohol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml400370w

Reference yield:

: 132259-54-2,287114-24-3
exo-(8-benzyl-8-aza-bicyclo[3.2.1]oct-3-yl)-carbamic acid tert-butyl ester

: 1519003-88-3
C₂₈H₄₄N₄O

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / methanol; 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: phosphorus pentachloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4: dichloromethane; tert-Amyl alcohol / 0 - 20 °C / Inert atmosphere

5: acetic acid / ethyl acetate / 0.5 h / 80 °C / Inert atmosphere

With hydrogenchloride; phosphorus pentachloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; methanol; tert-Amyl alcohol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ml400370w