N-(4-(3-((dimethylamino)methyl)phenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide trifluoroacetate

Base Information

Chemical Name:N-(4-(3-((dimethylamino)methyl)phenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide trifluoroacetate
CAS No.:1391979-89-7
Molecular Formula:C₂HF₃O₂*C₂₉H₂₈F₃N₃O₄S₂
Molecular Weight:717.71
Hs Code.:

Synonyms:N-(4-(3-((dimethylamino)methyl)phenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide trifluoroacetate

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Chemical Property of N-(4-(3-((dimethylamino)methyl)phenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide trifluoroacetate

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Technology Process of N-(4-(3-((dimethylamino)methyl)phenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide trifluoroacetate

There total 12 articles about N-(4-(3-((dimethylamino)methyl)phenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: 383135-47-5
2-[4-(ethanesulfonyl)phenyl]acetic acid

: 4-(3-((dimethylamino)methyl)phenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-amine

: 1391979-89-7
N-(4-(3-((dimethylamino)methyl)phenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide trifluoroacetate

Guidance literature:: 2-[4-(ethanesulfonyl)phenyl]acetic acid; 4-(3-((dimethylamino)methyl)phenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-amine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 35 ℃; for 48h;

With trifluoroacetic acid; In acetonitrile;
DOI:10.1016/j.bmc.2015.07.068

Reference yield:

: 383135-47-5
2-[4-(ethanesulfonyl)phenyl]acetic acid

: 4-(3-((dimethylamino)methyl)phenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-amine

: 76-05-1
trifluoroacetic acid

: 1391979-89-7
N-(4-(3-((dimethylamino)methyl)phenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide trifluoroacetate

Guidance literature:: 2-[4-(ethanesulfonyl)phenyl]acetic acid; 4-(3-((dimethylamino)methyl)phenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-amine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; Reflux;

trifluoroacetic acid;

Reference yield:

: 585-74-0
3-Methylacetophenone

: 1391979-89-7
N-(4-(3-((dimethylamino)methyl)phenyl)-5-(2-(trifluoromethyl)phenoxy)thiazol-2-yl)-2-(4-(ethylsulfonyl)phenyl)acetamide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / acetonitrile / 20 h / 85 °C / Inert atmosphere

2: potassium carbonate / dichloromethane / 20 °C

3: bromine; acetic acid / 10 °C

4: ethanol / 80 °C

5: N-Bromosuccinimide / tetrahydrofuran / 0.5 h / 20 °C

6: caesium carbonate / acetone / 45 °C

7: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / Reflux

With N-Bromosuccinimide; bromine; potassium carbonate; benzotriazol-1-ol; caesium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrahydrofuran; ethanol; dichloromethane; acetone; acetonitrile;