Technology Process of (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3,4-di-O-acetyl-2,6-dideoxyhexopyranoside
There total 15 articles about (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3,4-di-O-acetyl-2,6-dideoxyhexopyranoside which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride;
In
benzene;
at 55 ℃;
for 48h;
DOI:10.1016/0008-6215(89)80063-1
- Guidance literature:
-
With
2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride;
In
benzene;
at 55 ℃;
for 48h;
DOI:10.1016/0008-6215(89)80063-1
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 10.3 g / acide p-toluenesulfonique / benzene / 2.5 h / 20 °C
2: 30 percent / fluorure d'argent, pyridine / 168 h / 20 °C
3: H2 / nickel de Raney / methanol / 15 h / 1 Torr
4: 1.) triethylamine 2.) resine IR 45 OH(1-) / 1.) CH2Cl2, 10min, 20 deg C, 2.) methanol
5: 82 percent / H2 / charbon palladie 10percent / ethyl acetate / 18 h
6: 1.) pyridine, 2.) acide p-toluenesulfonique / 1.) 18h, 20 deg C, 2.) benzene, CH2Cl2, 30min, 20 deg C
With
pyridine; acide p-toluenesulfonique; resine IR 45 OH(1-); hydrogen; silver fluoride; triethylamine;
palladium on activated charcoal; nickel de Raney;
In
methanol; ethyl acetate; benzene;
DOI:10.1016/0040-4020(81)85015-6
