2',3'-di-O-acetyl-5'-O-trityl-1-[(2-methoxyethoxy)methyl]inosine

Base Information

• Chemical Name: 2',3'-di-O-acetyl-5'-O-trityl-1-[(2-methoxyethoxy)methyl]inosine
• CAS No.: 911430-71-2
• Molecular Formula: C₃₇H₃₈N₄O₉
• Molecular Weight: 682.73
• Mol file: 911430-71-2.mol

Synonyms:2',3'-di-O-acetyl-5'-O-trityl-1-[(2-methoxyethoxy)methyl]inosine

Chemical Property of 2',3'-di-O-acetyl-5'-O-trityl-1-[(2-methoxyethoxy)methyl]inosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2',3'-di-O-acetyl-5'-O-trityl-1-[(2-methoxyethoxy)methyl]inosine

There total 1 articles about 2',3'-di-O-acetyl-5'-O-trityl-1-[(2-methoxyethoxy)methyl]inosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2',3'-bis-O-acetyl-5'-O-tritylinosine (4234-39-3) + 2-Methoxyethoxymethyl chloride (3970-21-6) → 2',3'-di-O-acetyl-5'-O-trityl-1-[(2-methoxyethoxy)methyl]inosine (911430-71-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/jm0605379

Reference yield: 42.0%

2',3'-di-O-acetyl-5'-O-trityl-1-[(2-methoxyethoxy)methyl]inosine (911430-71-2) → 1-[(2-methoxyethoxy)methyl]-5'-O-tritylinosine + 5-amino-1-(5'-O-trityl-β-D-ribofuranosyl)imidazol-4-[N-(2-methoxyethoxy)methyl]carboxamide

Guidance literature:

With sodium hydroxide; Heating;

DOI:10.1021/jm0605379

Reference yield: 20.0%

2',3'-di-O-acetyl-5'-O-trityl-1-[(2-methoxyethoxy)methyl]inosine (911430-71-2) → 5-amino-1-(5-O-trityl-β-D-ribofuranosyl)imidazole-4-carboxamide

Guidance literature:

With sodium hydroxide; for 6h; Heating;

DOI:10.1021/jm0605379

upstream raw materials:

2',3'-bis-O-acetyl-5'-O-tritylinosine

2-Methoxyethoxymethyl chloride