(S)-4-(2-[[2-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-ethyl]-(2,6-bis(carbazol-9-yl)-hexanoyl)-amino]-ethylcarbamoyl)-2-(pyrrol-1-yl)-butyric acid benzyl ester

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Chemical Name:(S)-4-(2-[[2-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-ethyl]-(2,6-bis(carbazol-9-yl)-hexanoyl)-amino]-ethylcarbamoyl)-2-(pyrrol-1-yl)-butyric acid benzyl ester
CAS No.:1346772-36-8
Molecular Formula:C₆₆H₆₇N₇O₇
Molecular Weight:1070.3
Hs Code.:

(S)-4-(2-[[2-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-ethyl]-(2,6-bis(carbazol-9-yl)-hexanoyl)-amino]-ethylcarbamoyl)-2-(pyrrol-1-yl)-butyric acid benzyl ester

Synonyms:(S)-4-(2-[[2-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-ethyl]-(2,6-bis(carbazol-9-yl)-hexanoyl)-amino]-ethylcarbamoyl)-2-(pyrrol-1-yl)-butyric acid benzyl ester

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Chemical Property of (S)-4-(2-[[2-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-ethyl]-(2,6-bis(carbazol-9-yl)-hexanoyl)-amino]-ethylcarbamoyl)-2-(pyrrol-1-yl)-butyric acid benzyl ester

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Technology Process of (S)-4-(2-[[2-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-ethyl]-(2,6-bis(carbazol-9-yl)-hexanoyl)-amino]-ethylcarbamoyl)-2-(pyrrol-1-yl)-butyric acid benzyl ester

There total 4 articles about (S)-4-(2-[[2-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-ethyl]-(2,6-bis(carbazol-9-yl)-hexanoyl)-amino]-ethylcarbamoyl)-2-(pyrrol-1-yl)-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 917201-75-3
4-{2-[2-((S)-4-benzyloxycarbonyl-4-pyrrol-1-yl-butyrylamino)-ethylamino]-ethylcarbamoyl}-(S)-2-pyrrol-1-yl-butyric acid benzyl ester

: 289910-87-8
(S)-2,6-Bis-carbazol-9-yl-hexanoic acid

: 1346772-36-8
(S)-4-(2-[[2-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-ethyl]-(2,6-bis(carbazol-9-yl)-hexanoyl)-amino]-ethylcarbamoyl)-2-(pyrrol-1-yl)-butyric acid benzyl ester

Guidance literature:: (S)-2,6-Bis-carbazol-9-yl-hexanoic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; for 0.666667h; Inert atmosphere;

4-{2-[2-((S)-4-benzyloxycarbonyl-4-pyrrol-1-yl-butyrylamino)-ethylamino]-ethylcarbamoyl}-(S)-2-pyrrol-1-yl-butyric acid benzyl ester; With triethylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.tetlet.2011.10.047

Reference yield:

: 866139-30-2
(S)-2-pyrrol-1-yl-pentanedioic acid 1-benzyl ester

: 1346772-36-8
(S)-4-(2-[[2-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-ethyl]-(2,6-bis(carbazol-9-yl)-hexanoyl)-amino]-ethylcarbamoyl)-2-(pyrrol-1-yl)-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0.67 h / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0.67 h / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1016/j.tetlet.2011.10.047

Reference yield:

: 56-87-1,3506-25-0
L-lysine

: 1346772-36-8
(S)-4-(2-[[2-((S)-4-benzyloxycarbonyl-4-(pyrrol-1-yl)-butyrylamino)-ethyl]-(2,6-bis(carbazol-9-yl)-hexanoyl)-amino]-ethylcarbamoyl)-2-(pyrrol-1-yl)-butyric acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; acetic acid / 1,4-dioxane; water / 24 h / 20 °C / Reflux

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0.67 h / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; water; 1.1: Clauson-Kaas reaction;
DOI:10.1016/j.tetlet.2011.10.047