10,10-Difluorothromboxane A2

Base Information

Chemical Name:10,10-Difluorothromboxane A2
CAS No.:121573-36-2
Molecular Formula:C₂₀H₃₀F₂O₅
Molecular Weight:388.452
Hs Code.:

Synonyms:10,10-difluoro-TXA2;10,10-difluorothromboxane A2;10,10-difluorothromboxane A2, (5E,9alpha,11alpha,13E,15R)-isomer;10,10-difluorothromboxane A2, (5E,9alpha,11alpha,13E,15S)-isomer;10,10-difluorothromboxane A2, (5Z,9alpha,11alpha,13E,15R)-isomer

Suppliers and Price of 10,10-Difluorothromboxane A2

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 10,10-Difluorothromboxane A2

Chemical Property:

Vapor Pressure:6.56E-12mmHg at 25°C
Boiling Point:495.8°C at 760 mmHg
Flash Point:253.7°C
PSA：75.99000
Density:1.19g/cm³
LogP:4.06020
XLogP3:3.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:12
Exact Mass:388.20613038
Heavy Atom Count:27
Complexity:535

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC(C=CC1C(C2C(C(O1)O2)(F)F)CC=CCCCC(=O)O)O
Isomeric SMILES:CCCCC[C@@H](/C=C/[C@@H]1[C@H]([C@H]2C([C@@H](O1)O2)(F)F)C/C=C\CCCC(=O)O)O

Technology Process of 10,10-Difluorothromboxane A2

There total 11 articles about 10,10-Difluorothromboxane A2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121573-20-4
Acetic acid (1R,3S,4R,5R)-7,7-difluoro-4-hydroxymethyl-2,6-dioxa-bicyclo[3.1.1]hept-3-ylmethyl ester

: 121573-36-2
10,10-difluorothromboxane A₂

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / pyridine

2: dimethylformamide / 18 h / 42 °C

3: DIBAL-H / -25 - 22 °C

4: 1.) Lithium hexamethyldisilazide / 1.) THF, 2.) methylation

5: Swern oxidation

7: LiAlH₄ complex of (S)-(-)-1,1'-bi-2-naphthol / tetrahydrofuran

8: NaOH / methanol; H₂O

With pyridine; sodium hydroxide; LiAlH₄ complex of (S)-(-)-1,1'-bi-2-naphthol; diisobutylaluminium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ja00194a062

Reference yield:

: 121573-23-7
Acetic acid (1R,3S,4R,5R)-4-cyanomethyl-7,7-difluoro-2,6-dioxa-bicyclo[3.1.1]hept-3-ylmethyl ester

: 121573-36-2
10,10-difluorothromboxane A₂

Guidance literature:: Multi-step reaction with 6 steps

1: DIBAL-H / -25 - 22 °C

2: 1.) Lithium hexamethyldisilazide / 1.) THF, 2.) methylation

3: Swern oxidation

5: LiAlH₄ complex of (S)-(-)-1,1'-bi-2-naphthol / tetrahydrofuran

6: NaOH / methanol; H₂O

With sodium hydroxide; LiAlH₄ complex of (S)-(-)-1,1'-bi-2-naphthol; diisobutylaluminium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water;
DOI:10.1021/ja00194a062

Reference yield:

: 121573-22-6
Acetic acid (1R,3S,4R,5R)-7,7-difluoro-4-methanesulfonyloxymethyl-2,6-dioxa-bicyclo[3.1.1]hept-3-ylmethyl ester

: 121573-36-2
10,10-difluorothromboxane A₂

Guidance literature:: Multi-step reaction with 7 steps

1: dimethylformamide / 18 h / 42 °C

2: DIBAL-H / -25 - 22 °C

3: 1.) Lithium hexamethyldisilazide / 1.) THF, 2.) methylation

4: Swern oxidation

6: LiAlH₄ complex of (S)-(-)-1,1'-bi-2-naphthol / tetrahydrofuran

7: NaOH / methanol; H₂O

With sodium hydroxide; LiAlH₄ complex of (S)-(-)-1,1'-bi-2-naphthol; diisobutylaluminium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/ja00194a062