(S)-1-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

Base Information

Chemical Name:(S)-1-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide
CAS No.:1398717-81-1
Molecular Formula:C₂₈H₃₇N₅O
Molecular Weight:459.635
Hs Code.:

Synonyms:(S)-1-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

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Chemical Property of (S)-1-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

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Technology Process of (S)-1-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

There total 12 articles about (S)-1-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1398718-36-9
(S)-(9H-fluoren-9-yl)methyl 1-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)-biphenyl-4-yl)ethylcarbamoyl)cyclohexylcarbamate

: 1398717-81-1
(S)-1-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

Guidance literature:: With piperidine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 24250-84-8
H-p-BrPhe-OH

: 1398717-81-1
(S)-1-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: thionyl chloride / Reflux

2: sodium hydrogencarbonate / acetone / 20 °C

3: ammonia; methanol / 0.25 h / -50 - 20 °C

4: triethylamine; trifluoroacetic anhydride / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere

5: sodium carbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide; water / 3 h / 100 °C

6: formic acid / 4 h / 40 °C

7: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / dichloromethane / 0 - 20 °C

8: piperidine / dichloromethane / 1 h / 20 °C

With piperidine; methanol; formic acid; thionyl chloride; ammonia; sodium hydrogencarbonate; sodium carbonate; triethylamine; trifluoroacetic anhydride; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 589-15-1
1-bromomethyl-4-bromobenzene

: 1398717-81-1
(S)-1-amino-N-(1-cyano-2-(4'-((4-methylpiperazin-1-yl)methyl)biphenyl-4-yl)ethyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: sodium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / Inert atmosphere; Reflux

3: sodium carbonate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide; water / 3 h / 100 °C

4: formic acid / 4 h / 40 °C

5: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / dichloromethane / 0 - 20 °C

6: piperidine / dichloromethane / 1 h / 20 °C

With piperidine; formic acid; sodium acetate; sodium carbonate; potassium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;