ethyl cis-6-aza-7-(4-bromophenyl)-2{[(4-chlorophenyl)amino]carbonylamino}-5-oxaspiro[3.4]oct-6-ene-2-carboxylate

Base Information

Chemical Name:ethyl cis-6-aza-7-(4-bromophenyl)-2{[(4-chlorophenyl)amino]carbonylamino}-5-oxaspiro[3.4]oct-6-ene-2-carboxylate
CAS No.:281207-73-6
Molecular Formula:C₂₂H₂₁BrClN₃O₄
Molecular Weight:506.783
Hs Code.:

Synonyms:ethyl cis-6-aza-7-(4-bromophenyl)-2{[(4-chlorophenyl)amino]carbonylamino}-5-oxaspiro[3.4]oct-6-ene-2-carboxylate

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Chemical Property of ethyl cis-6-aza-7-(4-bromophenyl)-2{[(4-chlorophenyl)amino]carbonylamino}-5-oxaspiro[3.4]oct-6-ene-2-carboxylate

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Technology Process of ethyl cis-6-aza-7-(4-bromophenyl)-2{[(4-chlorophenyl)amino]carbonylamino}-5-oxaspiro[3.4]oct-6-ene-2-carboxylate

There total 4 articles about ethyl cis-6-aza-7-(4-bromophenyl)-2{[(4-chlorophenyl)amino]carbonylamino}-5-oxaspiro[3.4]oct-6-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 104-12-1
p-chlorphenylisocyanate

: 281207-66-7
ethyl cis-2-amino-6-aza-7-(4-bromophenyl)-5-oxaspiro[3.4]oct-6-ene-2-carboxylate

: 281207-73-6
ethyl cis-6-aza-7-(4-bromophenyl)-2{[(4-chlorophenyl)amino]carbonylamino}-5-oxaspiro[3.4]oct-6-ene-2-carboxylate

Guidance literature:: In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jo000152c

Reference yield:

: 25062-46-8,40979-16-6,34158-73-1
4-bromobenzaldehyde oxime

: 281207-73-6
ethyl cis-6-aza-7-(4-bromophenyl)-2{[(4-chlorophenyl)amino]carbonylamino}-5-oxaspiro[3.4]oct-6-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / Et₃N; bleach / CH₂Cl₂ / 10 - 20 °C

2: 94 percent / TFA / CH₂Cl₂ / 0 - 20 °C

3: 97 percent / CH₂Cl₂ / 0.5 h / 20 °C

With sodium hypochlorite; triethylamine; trifluoroacetic acid; In dichloromethane; 1: Cycloaddition / 2: Hydrolysis / 3: Addition;
DOI:10.1021/jo000152c

Reference yield:

: 281207-62-3
ethyl 1-[(tert-butoxy)carbonylamino]-3-methylenecyclobutanecarboxylate

: 281207-73-6
ethyl cis-6-aza-7-(4-bromophenyl)-2{[(4-chlorophenyl)amino]carbonylamino}-5-oxaspiro[3.4]oct-6-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / Et₃N; bleach / CH₂Cl₂ / 10 - 20 °C

2: 94 percent / TFA / CH₂Cl₂ / 0 - 20 °C

3: 97 percent / CH₂Cl₂ / 0.5 h / 20 °C

With sodium hypochlorite; triethylamine; trifluoroacetic acid; In dichloromethane; 1: Cycloaddition / 2: Hydrolysis / 3: Addition;
DOI:10.1021/jo000152c