4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylic acid

Base Information

• Chemical Name: 4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylic acid
• CAS No.: 113457-84-4
• Molecular Formula: C₁₉H₁₆N₂O₄
• Molecular Weight: 336.347
• Mol file: 113457-84-4.mol

Synonyms:4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylic acid

Chemical Property of 4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylic acid

There total 1 articles about 4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methyl 4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate (102357-93-7) → 4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylic acid (113457-84-4)

Guidance literature:

With potassium hydroxide; In methanol; water; Heating;

DOI:10.1016/S0040-4039(00)96312-3

Reference yield: 73.0%

4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylic acid (113457-84-4) + benzyl 4-benzyloxy-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate (102357-94-8) → benzyl 4-benzyloxy-3-<(4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indol-7-yl)carbonyl>-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate (113457-85-5)

Guidance literature:

With CMC; In dichloromethane; N,N-dimethyl-formamide; Ambient temperature;

Reference yield:

4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylic acid (113457-84-4) → benzyl 4-benzyloxy-3-<(4-benzyloxy-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indol-7-yl)carbonyl>-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate (113457-86-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / CMC / CH₂Cl₂; dimethylformamide / Ambient temperature

2: 74 percent / sodium cyanoborohydride / acetic acid / 1 h / Ambient temperature

With sodium cyanoborohydride; In dichloromethane; acetic acid; N,N-dimethyl-formamide;

upstream raw materials:

methyl 4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate

Downstream raw materials:

benzyl 4-benzyloxy-3-<(4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indol-7-yl)carbonyl>-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate

6-(6-Carbamoyl-5-hydroxy-4-methoxy-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carbonyl)-5-hydroxy-4-methoxy-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid

benzyl 4-benzyloxy-3-<(4-benzyloxy-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indol-7-yl)carbonyl>-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate

benzyl 4-benzyloxy-3-<(4-benzyloxy-3-carbamoyl-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indol-7-yl)carbonyl>-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate