(S)-5-chloro-α-(cyclopropylethynyl)-2-amino-α-(trifluoromethyl) benzenemethanol hydrocloride

Base Information

• Chemical Name: (S)-5-chloro-α-(cyclopropylethynyl)-2-amino-α-(trifluoromethyl) benzenemethanol hydrocloride
• CAS No.: 220978-02-9
• Molecular Formula: C₁₃H₁₁ClF₃NO*ClH
• Molecular Weight: 326.146
• Mol file: 220978-02-9.mol

Synonyms:(S)-5-chloro-α-(cyclopropylethynyl)-2-amino-α-(trifluoromethyl) benzenemethanol hydrocloride

Chemical Property of (S)-5-chloro-α-(cyclopropylethynyl)-2-amino-α-(trifluoromethyl) benzenemethanol hydrocloride

Chemical Property:

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-5-chloro-α-(cyclopropylethynyl)-2-amino-α-(trifluoromethyl) benzenemethanol hydrocloride

There total 1 articles about (S)-5-chloro-α-(cyclopropylethynyl)-2-amino-α-(trifluoromethyl) benzenemethanol hydrocloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.7%

(2S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol (209414-27-7,927812-33-7,154598-58-0) → (S)-5-chloro-α-(cyclopropylethynyl)-2-amino-α-(trifluoromethyl) benzenemethanol hydrocloride (220978-02-9)

Guidance literature:

With hydrogenchloride; In Isopropyl acetate; isopropyl alcohol; at 20 ℃; for 18h; Product distribution / selectivity;

Reference yield:

(S)-5-chloro-α-(cyclopropylethynyl)-2-amino-α-(trifluoromethyl) benzenemethanol hydrocloride (220978-02-9) + bis(trichloromethyl) carbonate (32315-10-9) → efavirenz (154598-52-4,154635-17-3)

Guidance literature:

With potassium hydrogencarbonate; In water; toluene; at 20 ℃; for 2h;

upstream raw materials:

(2S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol

Downstream raw materials:

efavirenz