[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-(6-methoxy-pyridin-3-yl)-methanone

Base Information

Chemical Name:[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-(6-methoxy-pyridin-3-yl)-methanone
CAS No.:915412-25-8
Molecular Formula:C₃₈H₄₄N₂O₄Si
Molecular Weight:620.864
Hs Code.:

Synonyms:[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-(6-methoxy-pyridin-3-yl)-methanone

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Chemical Property of [3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-(6-methoxy-pyridin-3-yl)-methanone

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Technology Process of [3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-(6-methoxy-pyridin-3-yl)-methanone

There total 7 articles about [3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-(6-methoxy-pyridin-3-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 915412-24-7
[3-bromo-5-(4-methoxy-benzyloxy)-phenyl]-(6-methoxy-pyridin-3-yl)-methanone

: 690632-17-8
4-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)-1-(triisopropylsilyl)-1H-indole

: 915412-25-8
[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-(6-methoxy-pyridin-3-yl)-methanone

Guidance literature:: With potassium phosphate; 2’-(dimethylamino)-2-biphenylylpalladium(II) chloride dinorbornylphosphine complex; In 1,4-dioxane; water; for 24h; Heating / reflux;

Reference yield:

: 52488-36-5
4-bromo-1H-indole

: 915412-25-8
[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-(6-methoxy-pyridin-3-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 4 h / 90 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 - 5 °C

2.2: 0 - 20 °C

3.1: potassium phosphate / chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 24 h / Heating / reflux

With potassium phosphate; potassium acetate; sodium hydride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II); In tetrahydrofuran; 1,4-dioxane; water; dimethyl sulfoxide; 3.1: Suzuki Coupling;

Reference yield:

: 915410-93-4
1,3-dibromo-5-((4-methoxybenzyl)oxy)-benzene

: 915412-25-8
[3-(4-methoxy-benzyloxy)-5-(1-triisopropylsilanyl-1H-indol-4-yl)-phenyl]-(6-methoxy-pyridin-3-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -76 °C

1.2: 1 h / -78 - 20 °C

2.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

3.1: potassium phosphate / chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II) / 1,4-dioxane; water / 24 h / Heating / reflux

With potassium phosphate; n-butyllithium; Dess-Martin periodane; chloro(di-2-norbornylphosphino)(2'dimethylamino-1,1'-biphenyl-2-yl)palladium(II); In 1,4-dioxane; diethyl ether; hexane; dichloromethane; water; 3.1: Suzuki Coupling;