3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutanone

Base Information

Chemical Name:3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutanone
CAS No.:1309652-51-4
Molecular Formula:C₂₅H₂₂N₄O₂
Molecular Weight:410.475
Hs Code.:

Synonyms:3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutanone

Suppliers and Price of 3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutanone

There total 8 articles about 3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R,S)-(Z)-3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]-1-hydroxymethyl-cyclobutanol

: 1309652-51-4
3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutanone

Guidance literature:: With sodium periodate; In tetrahydrofuran; water; at 20 ℃; for 19h;

Reference yield:

: 6665-86-7,66585-10-2
7-hydroxyflavone

: 1309652-51-4
3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutanone

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 45 h / 20 °C / 760.05 Torr

2: dmap; 2,6-dimethylpyridine / dichloromethane / 1 h / 0 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

4: potassium phosphate; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere

5: sodium periodate / water; tetrahydrofuran / 19 h / 20 °C

With 2,6-dimethylpyridine; dmap; potassium phosphate; sodium periodate; hydrogen; potassium acetate; sodium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 4: Suzuki Coupling;

Reference yield:

: 6515-36-2,2545-13-3
7-hydroxy-2-phenyl-chroman-4-one

: 1309652-51-4
3-[4-amino-5-(2-phenyl-chroman-7-yl)-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane-THF / tetrahydrofuran / 20 °C / Cooling with ice

2.1: triethylsilane / dichloromethane / 0.08 h

2.2: 0.5 h / 20 °C

3.1: dmap; 2,6-dimethylpyridine / dichloromethane / 1 h / 0 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

5.1: potassium phosphate; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere

6.1: sodium periodate / water; tetrahydrofuran / 19 h / 20 °C

With 2,6-dimethylpyridine; triethylsilane; dmap; potassium phosphate; sodium periodate; borane-THF; potassium acetate; sodium carbonate; 1,1'-bis-(diphenylphosphino)ferrocene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 5.1: Suzuki Coupling;