3-(4-amino-3-methoxy-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

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Chemical Name:3-(4-amino-3-methoxy-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
CAS No.:330792-81-9
Molecular Formula:C₂₃H₃₂N₈O
Molecular Weight:436.56
Hs Code.:

3-(4-amino-3-methoxy-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1<i>H</i>-pyrazolo[3,4-<i>d</i>]pyrimidin-4-ylamine

Synonyms:3-(4-amino-3-methoxy-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

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Chemical Property of 3-(4-amino-3-methoxy-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

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Technology Process of 3-(4-amino-3-methoxy-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

There total 6 articles about 3-(4-amino-3-methoxy-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 330793-47-0
(4-{4-amino-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxy-phenyl)-carbamic acid tert-butyl ester

: 330792-81-9
3-(4-amino-3-methoxy-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(02)00196-8

Reference yield:

: 2380-63-4
4-Aminopyrazolo<3,4-d>pyrimidin

: 330792-81-9
3-(4-amino-3-methoxy-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1: NIS / dimethylformamide / 50 °C

2: Ph₃P; DEAD / tetrahydrofuran

3: 50 percent / 5 N aq. HCl / acetone

4: 17 percent / Na(OAc)3BH; AcOH / 1,2-dichloro-ethane

5: 77 percent / Pd(PPh₃)4; Na₂CO₃ / 1,2-dimethoxy-ethane; H₂O / 80 °C

6: 74 percent / TFA / CH₂Cl₂

With hydrogenchloride; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; 2: Mitsunobu coupling / 5: Suzuki coupling;
DOI:10.1016/S0960-894X(02)00196-8

Reference yield:

: 151266-23-8
4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine

: 330792-81-9
3-(4-amino-3-methoxy-phenyl)-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1: Ph₃P; DEAD / tetrahydrofuran

2: 50 percent / 5 N aq. HCl / acetone

3: 17 percent / Na(OAc)3BH; AcOH / 1,2-dichloro-ethane

4: 77 percent / Pd(PPh₃)4; Na₂CO₃ / 1,2-dimethoxy-ethane; H₂O / 80 °C

5: 74 percent / TFA / CH₂Cl₂

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 1,2-dichloro-ethane; acetone; 1: Mitsunobu coupling / 4: Suzuki coupling;
DOI:10.1016/S0960-894X(02)00196-8