Chemical Property of Sucralfate
Chemical Property:
- Appearance/Colour:White amorphous powder.
- Vapor Pressure:0Pa at 25℃
- Boiling Point:1990℃ at 101.325kPa
- PKA:pKa = 0.43 to 1.19(at 25℃)
- PSA：1435.37000
- Density:0.338 at 20℃
- LogP:-6.18770
- Storage Temp.:2-8°C
- Solubility.:Practically insoluble in water, in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of mineral acids and alkali hydroxides.
- Purity/Quality:
-
99% *data from raw suppliers
Sucrose Octasulfate Aluminium Salt *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
-
Description
Sucralfate is a complex of the sulfuric acid ester of sucrose and aluminum hydroxide.
Secondary polymerization with aluminum hydroxide forms intermolecular bridges between
molecules of sulfate esters with aluminum. Limited dissociation of the complex occurs in
gastric acid, but these anionic sulfate esters form insoluble adherent complexes with the
proteinaceous exudate at the abraded surface of a crater of the ulcerated area in the
stomach. This physical complex protects the ulcer from the erosive action of pepsin and bile
salts. Sucralfate also stimulates synthesis and release of prostaglandins, bicarbonate, and
epidermal and fibroblast growth factors. Significant ulcer healing effects are noted in
placebo-controlled trials. Only small amounts of sucralfate are absorbed systemically. In renal
impairment, there is a risk of accumulation of absorbed aluminum from the drug. Sucralfate
reduces absorption of other drugs, including H2 antihistamines, quinolone antibiotics,
phenytoin, and perhaps, warfarin Sucralfate is a basic aluminum sucrose sulfate complex that has gastroprotective activity. It inhibits rat pepsin in a concentration-dependent manner and pepsin activity in isolated human gastric juice. It also inhibits ulcer formation induced by pyloric ligation, indomethacin , or cysteamine in rats. Sucralfate (5,600 mg/animal) is protective against neutral ethanol and acidified taurocholic acid-induced damage in a rat model of hydrochloric acid-induced gastric mucosal damage, increasing the pH and reducing the disappearance of hydrogen ions. Formulations containing sucralfate have been used as antacids in the treatment of duodenal ulcer.
-
Uses
antineoplastic, antileukemia An inhibitor of peptic hydrolysis and stomach acidity. Used as an antiulcerative Sucralfate, an aluminum salt of sucrose octasulfate, is used as an antacid and antiulcer medication. Bis- and tris-platinum complexes of sucrose show promise as antitumor agents. Sucrose monoesters are used in some pharmaceutical preparations.
-
Indications
Sucralfate (Carafate) is an aluminum hydroxide–sulfated
sucrose complex that is only minimally absorbed
from the GI tract. After exposure to gastric acid, the
compound becomes negatively charged, creating a viscous
adherent complex. This complex is believed to inhibit
back-diffusion of H .Other effects are a direct reduction
in pepsin activity and a slight rise in tissue
prostaglandin levels. Stimulation of a cytoprotection
mechanism may therefore assist mucosal healing. The
drug has no acid-buffering capacity.
-
Therapeutic Function
Antiulcer
-
Clinical Use
Sucralfate is frequently used for prophylaxis of
stress-induced gastritis in patients in intensive care
units. It has also been successfully used in small numbers
of patients as a suspension enema to treat radiation
proctitis.
-
Drug interactions
Potentially hazardous interactions with other drugs
Reduced absorption of digoxin, tetracyclines,
quinolones, coumarins, fosphenytoin and phenytoin
- give 2 hours after sucralfate.
