Technology Process of 5-[4-[2-(2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione
There total 7 articles about 5-[4-[2-(2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
pioglitazone imino;
With
water;
In
denatured spirit;
at 80 - 82 ℃;
for 18 - 20h;
Heating / reflux;
With
triethylamine;
In
denatured spirit; water;
at 40 - 50 ℃;
for 1h;
pH=7.3;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 58.5 percent / NaH / dimethylformamide / 1 h / 0 °C
2: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature
3: 1.) NaNO2, conc. HCl, 2.) Cu2O / 1.) acetone, water, 5 deg C, 30 min, 2.) acetone, water, 35 deg C
4: 2.) 2N HCl / 1.) sulfolane, 120 deg C, 10 h; 2.) sulfolane, 100 deg C, 8 h
With
copper(I) oxide; hydrogenchloride; hydrogen; sodium hydride; sodium nitrite;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.30.3580
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature
2: 1.) NaNO2, conc. HCl, 2.) Cu2O / 1.) acetone, water, 5 deg C, 30 min, 2.) acetone, water, 35 deg C
3: 2.) 2N HCl / 1.) sulfolane, 120 deg C, 10 h; 2.) sulfolane, 100 deg C, 8 h
With
copper(I) oxide; hydrogenchloride; hydrogen; sodium nitrite;
palladium on activated charcoal;
In
methanol;
DOI:10.1248/cpb.30.3580
