(S)-2-(4-nitro-benzoylamino)-pentanedioic acid 5-ethyl ester

Base Information

• Chemical Name: (S)-2-(4-nitro-benzoylamino)-pentanedioic acid 5-ethyl ester
• CAS No.: 936125-94-9
• Molecular Formula: C₁₄H₁₆N₂O₇
• Molecular Weight: 324.29
• Mol file: 936125-94-9.mol

Synonyms:(S)-2-(4-nitro-benzoylamino)-pentanedioic acid 5-ethyl ester

Chemical Property of (S)-2-(4-nitro-benzoylamino)-pentanedioic acid 5-ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (S)-2-(4-nitro-benzoylamino)-pentanedioic acid 5-ethyl ester

There total 1 articles about (S)-2-(4-nitro-benzoylamino)-pentanedioic acid 5-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

diethyl (4-nitrobenzoyl)-L-glutamate (7148-24-5) → (S)-2-(4-nitro-benzoylamino)-pentanedioic acid 5-ethyl ester (936125-94-9)

Guidance literature:

With water; triethylamine; lithium bromide; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2007.02.029

Reference yield:

(S)-2-(4-nitro-benzoylamino)-pentanedioic acid 5-ethyl ester (936125-94-9) → N-(4-nitro-benzoyl)-L-glutamic acid-5-hydrazide (52479-01-3)

Guidance literature:

With water; hydrazine hydrate;

DOI:10.1021/ja01175a010

Reference yield:

(S)-2-(4-nitro-benzoylamino)-pentanedioic acid 5-ethyl ester (936125-94-9) → N-[N-(4-nitro-benzoyl)-L-γ-glutamyl]-L-glutamic acid (52407-64-4)

Guidance literature:

Multi-step reaction with 3 steps

1: aqueous sodium hydrogencarbonate solution; hydrazine hydrate

2: aqueous hydrochloric acid; sodium nitrite / Behandeln des erhaltenen N-<4-Nitro-benzoyl>-L-glutaminsaeure-5-azids mit L-Glutaminsaeure-diaethylester in Aethylacetat

3: aq. NaOH solution

With hydrogenchloride; sodium hydroxide; sodium hydrogencarbonate; hydrazine hydrate; sodium nitrite;

DOI:10.1021/ja01175a010

upstream raw materials:

diethyl (4-nitrobenzoyl)-L-glutamate

Downstream raw materials:

N²-(4-nitro-benzoyl)-L-glutamine

N-(4-nitro-benzoyl)-L-glutamic acid-5-hydrazide

N-{O¹-ethyl-N-[O¹-ethyl-N-(4-nitro-benzoyl)-γ-L-glutamyl]-γ-L-glutamyl}-L-glutamic acid diethyl ester

N-[N-(4-nitro-benzoyl)-L-γ-glutamyl]-L-glutamic acid