N¹,N²-diphenyl-2-(N-phenyltridecanoylamido)isobutyramidine hydrochloride

Base Information

• Chemical Name: N¹,N²-diphenyl-2-(N-phenyltridecanoylamido)isobutyramidine hydrochloride
• CAS No.: 325146-33-6
• Molecular Formula: C₃₅H₄₇N₃O*ClH
• Molecular Weight: 562.239
• Mol file: 325146-33-6.mol

Synonyms:N¹,N²-diphenyl-2-(N-phenyltridecanoylamido)isobutyramidine hydrochloride

Chemical Property of N¹,N²-diphenyl-2-(N-phenyltridecanoylamido)isobutyramidine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹,N²-diphenyl-2-(N-phenyltridecanoylamido)isobutyramidine hydrochloride

There total 4 articles about N¹,N²-diphenyl-2-(N-phenyltridecanoylamido)isobutyramidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

n-tridecanoyl chloride (17746-06-4) + N1,N2-diphenyl-2-phenylaminoisobutyramidine → N1,N2-diphenyl-2-(N-phenyltridecanoylamido)isobutyramidine hydrochloride (325146-33-6)

Guidance literature:

In diethyl ether; at 5 - 20 ℃;

DOI:10.1016/j.bmcl.2013.02.053

Reference yield:

2-methyl-N-phenylacrylamide (1611-83-2) → N1,N2-diphenyl-2-(N-phenyltridecanoylamido)isobutyramidine hydrochloride (325146-33-6)

Guidance literature:

Multi-step reaction with 4 steps

1: phosphorus pentachloride / benzene / 7 h / 5 - 50 °C

2: diethyl ether / 5 - 20 °C

3: ammonium hydroxide / dichloromethane / 3 h

4: diethyl ether / 5 - 20 °C

With ammonium hydroxide; phosphorus pentachloride; In diethyl ether; dichloromethane; benzene;

DOI:10.1016/j.bmcl.2013.02.053

Reference yield:

tridecanoic acid (638-53-9) → N1,N2-diphenyl-2-(N-phenyltridecanoylamido)isobutyramidine hydrochloride (325146-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / Heating

2: diethyl ether / 5 - 20 °C

With thionyl chloride; In diethyl ether;

DOI:10.1016/j.bmcl.2013.02.053

upstream raw materials:

2-methyl-N-phenylacrylamide

n-tridecanoyl chloride

tridecanoic acid