(1R,3R,5R,6R)-3-[(3,4-dichloro benzyl)oxy]-6-fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxamide

Base Information

Chemical Name:(1R,3R,5R,6R)-3-[(3,4-dichloro benzyl)oxy]-6-fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxamide
CAS No.:1308835-52-0
Molecular Formula:C₁₄H₁₂Cl₂FNO₃
Molecular Weight:332.159
Hs Code.:

Synonyms:(1R,3R,5R,6R)-3-[(3,4-dichloro benzyl)oxy]-6-fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxamide

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Chemical Property of (1R,3R,5R,6R)-3-[(3,4-dichloro benzyl)oxy]-6-fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxamide

Chemical Property:

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Technology Process of (1R,3R,5R,6R)-3-[(3,4-dichloro benzyl)oxy]-6-fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxamide

There total 6 articles about (1R,3R,5R,6R)-3-[(3,4-dichloro benzyl)oxy]-6-fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1308835-50-8
ethyl (1R,3R,5R,6R)-3-[(3,4-dichloro benzyl)oxy]-6-fluoro-2-oxo bicyclo[3.1.0]hexane-6-carboxylate

: 1308835-52-0
(1R,3R,5R,6R)-3-[(3,4-dichloro benzyl)oxy]-6-fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxamide

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 1h;

Reference yield:

: (1R,3R,5R,6R)-2-amino-2-cyano-3-[(3,4-dichloro benzyl)oxy]-6-fluorobicyclo[3.1.0]hexane-6-carboxamide citrate

: 1308835-52-0
(1R,3R,5R,6R)-3-[(3,4-dichloro benzyl)oxy]-6-fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxamide

Guidance literature:: With water; acetic acid; at 90 - 93 ℃; for 4.5h;

Reference yield:

: 1308835-38-2
ethyl (1R,5R,6R)-6-fluoro-2-[(trimethylsilyl)oxy]bicyclo[3.1.0]hex-2-ene-6-carboxylate

: 1308835-52-0
(1R,3R,5R,6R)-3-[(3,4-dichloro benzyl)oxy]-6-fluoro-2-oxobicyclo[3.1.0]hexane-6-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: dihydrogen peroxide / toluene / 1.33 h / 30 - 45 °C

2: trifluorormethanesulfonic acid / TETRAHYDROPYRANE / 1.75 h / 24 - 31 °C

3: ammonia / methanol / 1 h / 20 °C

With trifluorormethanesulfonic acid; ammonia; dihydrogen peroxide; In TETRAHYDROPYRANE; methanol; toluene;