(3R)-3,4-Dihydrobenzo[a]anthracene-3β,4α-diol

Base Information

• Chemical Name: (3R)-3,4-Dihydrobenzo[a]anthracene-3β,4α-diol
• CAS No.: 67335-42-6
• Molecular Formula: C₁₈H₁₄O₂
• Molecular Weight: 262.308
• Mol file: 67335-42-6.mol

Synonyms:(-)-trans-(3R,4R)-3,4-dihydroxy-3,4-dihydrobenz[a]anthracene;(3R,4R)-3,4-Dihydro-benzo[a]anthracene-3,4-diol;

Chemical Property of (3R)-3,4-Dihydrobenzo[a]anthracene-3β,4α-diol

Chemical Property:

• Vapor Pressure: 7.35E-12mmHg at 25°C
• Refractive Index: 1.5490 (estimate)
• Boiling Point: 525.2°C at 760 mmHg
• Flash Point: 257.2°C
• PSA: 40.46000
• Density: 1.367g/cm³
• LogP: 3.41410

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3R)-3,4-Dihydrobenzo[a]anthracene-3β,4α-diol

There total 15 articles about (3R)-3,4-Dihydrobenzo[a]anthracene-3β,4α-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

trans-3,4-dihydroxy-3,4-dihydrobenzanthracene diacetate (60967-85-3) → (+/-)-trans-3,4-dihydroxy-3,4-dihydrobenzanthracene (60967-89-7,64501-86-6,60839-18-1,67335-42-6,67335-43-7)

Guidance literature:

With sodium methylate; In tetrahydrofuran; methanol; for 0.166667h; Heating;

DOI:10.1021/jm00396a023

Reference yield: 95.0%

((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyloxy)-acetic acid (3R,4R)-3-[2-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyloxy)-acetoxy]-3,4-dihydro-benzo[a]anthracen-4-yl ester (80399-26-4) → (-)-trans-(3R,4R)-3,4-dihydroxy-3,4-dihydrobenzanthracene (67335-42-6)

Guidance literature:

With sodium methylate; In tetrahydrofuran; methanol; for 1h; Ambient temperature;

DOI:10.1021/jo00345a043

Reference yield: 83.5%

(-)-trans-(3R,4R)-3,4-diacetoxy-3,4-dihydrobenzanthracene (80433-92-7) → (-)-trans-(3R,4R)-3,4-dihydroxy-3,4-dihydrobenzanthracene (67335-42-6)

Guidance literature:

With methanol; ammonia; In tetrahydrofuran;

DOI:10.1021/jo00345a043

upstream raw materials:

benzanthracene-3,4-dione

trans-3,4-dihydroxy-3,4-dihydrobenzanthracene diacetate

3-hydroxybenzanthracene

3,7,12-trimethoxybenz[a]anthracene

Downstream raw materials:

benzanthracene-trans-3,4-dihydro-(8S,9S)-diol

(-)-(1S,2R,3R,4S)-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzanthracene

(-)-(1S,2R,3S,4R)-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzanthracene

(+)-(1R,2S,3R,4S)-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzanthracene