5-benzyloxybenzyl-1-(5'-O-trityl-3'-azido-2',3'-dideoxy-β-D-threo-pentafuranosyl)uracil

Base Information

Chemical Name:5-benzyloxybenzyl-1-(5'-O-trityl-3'-azido-2',3'-dideoxy-β-D-threo-pentafuranosyl)uracil
CAS No.:132163-53-2
Molecular Formula:C₄₂H₃₇N₅O₅
Molecular Weight:691.786
Hs Code.:

Synonyms:5-benzyloxybenzyl-1-(5'-O-trityl-3'-azido-2',3'-dideoxy-β-D-threo-pentafuranosyl)uracil

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Chemical Property of 5-benzyloxybenzyl-1-(5'-O-trityl-3'-azido-2',3'-dideoxy-β-D-threo-pentafuranosyl)uracil

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Technology Process of 5-benzyloxybenzyl-1-(5'-O-trityl-3'-azido-2',3'-dideoxy-β-D-threo-pentafuranosyl)uracil

There total 6 articles about 5-benzyloxybenzyl-1-(5'-O-trityl-3'-azido-2',3'-dideoxy-β-D-threo-pentafuranosyl)uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 132163-51-0
5'-O-trityl-5-benzyloxybenzyldeoxyuridine

: 132163-53-2
5-benzyloxybenzyl-1-(5'-O-trityl-3'-azido-2',3'-dideoxy-β-D-threo-pentafuranosyl)uracil

Guidance literature:: With lithium azide; carbon tetrabromide; triphenylphosphine; In N,N-dimethyl-formamide; at 35 ℃; for 24h;
DOI:10.1002/jhet.5570270609

Reference yield:

: 3601-89-6,4330-21-6,52304-86-6,3056-12-0,141846-57-3
Hoffer's chlorosugar

: 132163-53-2
5-benzyloxybenzyl-1-(5'-O-trityl-3'-azido-2',3'-dideoxy-β-D-threo-pentafuranosyl)uracil

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) hexamethyldisilazane, (NH₄)2SO₄ / 1.) reflux, 3 h, 2.) acetonitrile, reflux, 4 h

2: KOH / methanol / 3 h / Ambient temperature

3: pyridine / 0.75 h / 100 °C

4: 71 percent / Ph₃P, LiN₃, CBr₄ / dimethylformamide / 24 h / 35 °C

With pyridine; ammonium sulfate; potassium hydroxide; lithium azide; carbon tetrabromide; triphenylphosphine; 1,1,1,3,3,3-hexamethyl-disilazane; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570270609

Reference yield:

: 76-83-5
trityl chloride

: 132163-53-2
5-benzyloxybenzyl-1-(5'-O-trityl-3'-azido-2',3'-dideoxy-β-D-threo-pentafuranosyl)uracil

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 0.75 h / 100 °C

2: 71 percent / Ph₃P, LiN₃, CBr₄ / dimethylformamide / 24 h / 35 °C

With pyridine; lithium azide; carbon tetrabromide; triphenylphosphine; In N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570270609