(E)-N-(3-fluoro-4-(methylsulfonamido)benzyl)-3-(4-iodophenyl)acrylamide

Base Information

• Chemical Name: (E)-N-(3-fluoro-4-(methylsulfonamido)benzyl)-3-(4-iodophenyl)acrylamide
• CAS No.: 1165738-50-0
• Molecular Formula: C₁₇H₁₆FIN₂O₃S
• Molecular Weight: 474.295

Synonyms:(E)-N-(3-fluoro-4-(methylsulfonamido)benzyl)-3-(4-iodophenyl)acrylamide

Chemical Property of (E)-N-(3-fluoro-4-(methylsulfonamido)benzyl)-3-(4-iodophenyl)acrylamide

Chemical Property:

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Technology Process of (E)-N-(3-fluoro-4-(methylsulfonamido)benzyl)-3-(4-iodophenyl)acrylamide

There total 1 articles about (E)-N-(3-fluoro-4-(methylsulfonamido)benzyl)-3-(4-iodophenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(E)-4-iodocinnamic acid (113641-76-2) + (3-fluoro-4-(methylsulfonamido)phenyl)methanaminium chloride → (E)-N-(3-fluoro-4-(methylsulfonamido)benzyl)-3-(4-iodophenyl)acrylamide (1165738-50-0)

Guidance literature:

(E)-4-iodocinnamic acid; With 4-methyl-morpholine; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; for 4h;

(3-fluoro-4-(methylsulfonamido)phenyl)methanaminium chloride; In tetrahydrofuran; at 20 ℃; for 10h;

DOI:10.1016/j.bmc.2009.04.010

upstream raw materials:

(E)-4-iodocinnamic acid

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