(2-butyl-5-nitrobenzofuran-3-yl)-[4-(3-[²H₂]-3-hydroxypropoxy)phenyl]-methanone

Base Information

Chemical Name:(2-butyl-5-nitrobenzofuran-3-yl)-[4-(3-[²H₂]-3-hydroxypropoxy)phenyl]-methanone
CAS No.:1542232-30-3
Molecular Formula:C₂₂H₂₃NO₆
Molecular Weight:399.412
Hs Code.:

(2-butyl-5-nitrobenzofuran-3-yl)-[4-(3-[<sup>2</sup>H<sub>2</sub>]-3-hydroxypropoxy)phenyl]-methanone

Synonyms:(2-butyl-5-nitrobenzofuran-3-yl)-[4-(3-[²H₂]-3-hydroxypropoxy)phenyl]-methanone

Suppliers and Price of (2-butyl-5-nitrobenzofuran-3-yl)-[4-(3-[²H₂]-3-hydroxypropoxy)phenyl]-methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2-butyl-5-nitrobenzofuran-3-yl)-[4-(3-[²H₂]-3-hydroxypropoxy)phenyl]-methanone

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Technology Process of (2-butyl-5-nitrobenzofuran-3-yl)-[4-(3-[²H₂]-3-hydroxypropoxy)phenyl]-methanone

There total 1 articles about (2-butyl-5-nitrobenzofuran-3-yl)-[4-(3-[²H₂]-3-hydroxypropoxy)phenyl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1542232-29-0
3-[4-(2-butyl-5-nitro-benzofuran-3-carbonyl)phenoxy]-propionic acid

: 1542232-30-3
(2-butyl-5-nitrobenzofuran-3-yl)-[4-(3-[²H₂]-3-hydroxypropoxy)phenyl]-methanone

Guidance literature:: With [⁽²⁾H]borane - tetrahydrofuran (1/1); In tetrahydrofuran; for 5.5h; Inert atmosphere; Cooling with ice;
DOI:10.1002/jlcr.3090

Reference yield: 87.0%

: 1542232-30-3
(2-butyl-5-nitrobenzofuran-3-yl)-[4-(3-[²H₂]-3-hydroxypropoxy)phenyl]-methanone

: 98-59-9
p-toluenesulfonyl chloride

: 1542232-31-4
(2-butyl-5-nitrobenzofuran-3-yl)-[4-(3-[²H₂]-3-(4-methylphenylsulphonyloxy) propoxy) phenyl]-methanone

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 44h; Cooling with ice;
DOI:10.1002/jlcr.3090

Reference yield:

: 1542232-30-3
(2-butyl-5-nitrobenzofuran-3-yl)-[4-(3-[²H₂]-3-hydroxypropoxy)phenyl]-methanone

: 1542232-49-4
(5-amino-2-butyl-benzofuran-3-yl)-[4-(3-dibutylamino-3-[²H₂]-propoxy)-phenyl]-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 44 h / 0 - 20 °C / Cooling with ice

2: ethanol / 8 h / Reflux

3: tin(II) chloride dihdyrate / ethanol / 80 °C / Inert atmosphere

With tin(II) chloride dihdyrate; triethylamine; In ethanol; dichloromethane;
DOI:10.1002/jlcr.3090