tert-butyl 3-(3-(benzyloxycarbonylamino)phenyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(3-(benzyloxycarbonylamino)phenyl)piperidine-1-carboxylate
CAS No.:1271808-42-4
Molecular Formula:C₂₄H₃₀N₂O₄
Molecular Weight:410.513
Hs Code.:

Synonyms:tert-butyl 3-(3-(benzyloxycarbonylamino)phenyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 3-(3-(benzyloxycarbonylamino)phenyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 3-(3-(benzyloxycarbonylamino)phenyl)piperidine-1-carboxylate

There total 3 articles about tert-butyl 3-(3-(benzyloxycarbonylamino)phenyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 908334-19-0
3-(1-tert-butoxycarbonyl-3-piperidyl)benzoic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 1271808-42-4
tert-butyl 3-(3-(benzyloxycarbonylamino)phenyl)piperidine-1-carboxylate

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; In toluene; at 80 ℃;

Reference yield:

: 626-55-1,163928-56-1
3-Bromopyridine

: 1271808-42-4
tert-butyl 3-(3-(benzyloxycarbonylamino)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane / 12 h / 80 °C

2: acetic acid; hydrogen; palladium 10% on activated carbon / 100 °C / 7757.43 Torr

3: sodium hydrogencarbonate / tetrahydrofuran; water / 12 h / 20 °C

4: water; lithium hydroxide / tetrahydrofuran / 6 h / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 8 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; palladium 10% on activated carbon; water; hydrogen; sodium hydrogencarbonate; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene; 1: |Suzuki Coupling / 5: |Curtius Rearrangement;
DOI:10.1016/j.bmc.2019.05.021

Reference yield:

: 269410-00-6
3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzoic acid ethyl ester

: 1271808-42-4
tert-butyl 3-(3-(benzyloxycarbonylamino)phenyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane / 12 h / 80 °C

2: acetic acid; hydrogen; palladium 10% on activated carbon / 100 °C / 7757.43 Torr

3: sodium hydrogencarbonate / tetrahydrofuran; water / 12 h / 20 °C

4: water; lithium hydroxide / tetrahydrofuran / 6 h / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 8 h / 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diphenyl phosphoryl azide; palladium 10% on activated carbon; water; hydrogen; sodium hydrogencarbonate; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene; 1: |Suzuki Coupling / 5: |Curtius Rearrangement;
DOI:10.1016/j.bmc.2019.05.021