2-[2-(4-methylphenyl)-1,3,4-thiadiazol-5-yl]benzisoselenazol-3(2H)-one

Base Information

Chemical Name:2-[2-(4-methylphenyl)-1,3,4-thiadiazol-5-yl]benzisoselenazol-3(2H)-one
CAS No.:1370641-58-9
Molecular Formula:C₁₆H₁₁N₃O₂Se
Molecular Weight:356.242
Hs Code.:

Synonyms:2-[2-(4-methylphenyl)-1,3,4-thiadiazol-5-yl]benzisoselenazol-3(2H)-one

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Chemical Property of 2-[2-(4-methylphenyl)-1,3,4-thiadiazol-5-yl]benzisoselenazol-3(2H)-one

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Technology Process of 2-[2-(4-methylphenyl)-1,3,4-thiadiazol-5-yl]benzisoselenazol-3(2H)-one

There total 4 articles about 2-[2-(4-methylphenyl)-1,3,4-thiadiazol-5-yl]benzisoselenazol-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

: 1441-85-6
2-(chloroseleno)benzoyl chloride

: 33621-60-2
2-amino-5-(4-methylphenyl)-1,3,4-oxadiazole

: 1370641-58-9
2-[2-(4-methylphenyl)-1,3,4-thiadiazol-5-yl]benzisoselenazol-3(2H)-one

Guidance literature:: 2-amino-5-(4-methylphenyl)-1,3,4-oxadiazole; With n-butyllithium; In tetrahydrofuran; hexane; at -72 ℃; for 1h; Inert atmosphere;

2-(chloroseleno)benzoyl chloride; In tetrahydrofuran; hexane; at 20 ℃; for 6h;
DOI:10.1248/cpb.c12-00250

Reference yield:

: 2,2'-diselenodibenzoic acid

: 1370641-58-9
2-[2-(4-methylphenyl)-1,3,4-thiadiazol-5-yl]benzisoselenazol-3(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -72 °C / Inert atmosphere

2.2: 6 h / 20 °C

With n-butyllithium; thionyl chloride; In tetrahydrofuran; hexane;
DOI:10.1248/cpb.c12-00250

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 1370641-58-9
2-[2-(4-methylphenyl)-1,3,4-thiadiazol-5-yl]benzisoselenazol-3(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol; water / 1.5 h / 65 °C / pH 7

2.1: bromine; sodium acetate; acetic acid / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -72 °C / Inert atmosphere

3.2: 6 h / 20 °C

With n-butyllithium; bromine; sodium acetate; acetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; hexane; water;
DOI:10.1248/cpb.c12-00250