3-Benzyloxy-5-benzyloxymethoxymethyl-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenylamine

Base Information

• Chemical Name: 3-Benzyloxy-5-benzyloxymethoxymethyl-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenylamine
• CAS No.: 177957-83-4
• Molecular Formula: C₃₀H₄₁NO₄Si
• Molecular Weight: 507.745

Synonyms:3-Benzyloxy-5-benzyloxymethoxymethyl-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenylamine

Chemical Property of 3-Benzyloxy-5-benzyloxymethoxymethyl-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Benzyloxy-5-benzyloxymethoxymethyl-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenylamine

There total 15 articles about 3-Benzyloxy-5-benzyloxymethoxymethyl-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Dimethyl 5-hydroxyisophthalate (13036-02-7) → 3-Benzyloxy-5-benzyloxymethoxymethyl-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenylamine (177957-83-4)

Guidance literature:

Multi-step reaction with 14 steps

1: 98 percent / K₂CO₃ / acetone / 3 h / Heating

2: 88 percent / various solvent(s) / 5 h / Heating

3: 99 percent / K₂CO₃ / acetone / 3 h / Heating

4: 95 percent / 4 M NaOH / tetrahydrofuran / 5 h / Heating

5: 72 percent / Br₂, aq. NaHCO₃ / CHCl₃ / 0.08 h / 0 °C

6: Et₃N / tetrahydrofuran / 0.33 h / 0 °C

7: NaBH₄ / H₂O / 0.67 h / 0 °C

8: 85 percent / i-Pr₂EtN / CH₂Cl₂ / 8 h / Ambient temperature

9: 93 percent / Zn, NH₄Cl / ethanol; H₂O / 1 h / 40 °C

10: 76 percent / DPPA, Et₃N, molecular sieves / 1.) room temperature, 1.5 h, 2.) reflux, 5 h

11: 73 percent / OsO₄, NaIO₄ / dioxane; H₂O / 13 h / Ambient temperature

12: 100 percent / NaBH₄ / ethanol / 0.67 h / Ambient temperature

13: 97 percent / Et₃N, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

14: 1.) TBDMSOTf, Py, 2.) TBAF / 1.) CH₂Cl₂, room temperature, 4 h, 2.) THF, room temperature, 1 h

With pyridine; dmap; sodium hydroxide; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; molecular sieve; t-butyldimethylsiyl triflate; diphenyl-phosphinic acid; tetrabutyl ammonium fluoride; bromine; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; water; acetone;

DOI:10.1016/S0040-4020(97)00651-0

Reference yield:

5-Hydroxyisophthalic acid (618-83-7) → 3-Benzyloxy-5-benzyloxymethoxymethyl-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenylamine (177957-83-4)

Guidance literature:

Multi-step reaction with 15 steps

1: 100 percent / SOCl₂ / 1.5 h / Heating

2: 98 percent / K₂CO₃ / acetone / 3 h / Heating

3: 88 percent / various solvent(s) / 5 h / Heating

4: 99 percent / K₂CO₃ / acetone / 3 h / Heating

5: 95 percent / 4 M NaOH / tetrahydrofuran / 5 h / Heating

6: 72 percent / Br₂, aq. NaHCO₃ / CHCl₃ / 0.08 h / 0 °C

7: Et₃N / tetrahydrofuran / 0.33 h / 0 °C

8: NaBH₄ / H₂O / 0.67 h / 0 °C

9: 85 percent / i-Pr₂EtN / CH₂Cl₂ / 8 h / Ambient temperature

10: 93 percent / Zn, NH₄Cl / ethanol; H₂O / 1 h / 40 °C

11: 76 percent / DPPA, Et₃N, molecular sieves / 1.) room temperature, 1.5 h, 2.) reflux, 5 h

12: 73 percent / OsO₄, NaIO₄ / dioxane; H₂O / 13 h / Ambient temperature

13: 100 percent / NaBH₄ / ethanol / 0.67 h / Ambient temperature

14: 97 percent / Et₃N, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

15: 1.) TBDMSOTf, Py, 2.) TBAF / 1.) CH₂Cl₂, room temperature, 4 h, 2.) THF, room temperature, 1 h

With pyridine; dmap; sodium hydroxide; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; thionyl chloride; molecular sieve; t-butyldimethylsiyl triflate; diphenyl-phosphinic acid; tetrabutyl ammonium fluoride; bromine; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; water; acetone;

DOI:10.1016/S0040-4020(97)00651-0

Reference yield:

dimethyl 5-(prop-2-en-1-yloxy)benzene-1,3-dicarboxylate (21368-39-8) → 3-Benzyloxy-5-benzyloxymethoxymethyl-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenylamine (177957-83-4)

Guidance literature:

Multi-step reaction with 13 steps

1: 88 percent / various solvent(s) / 5 h / Heating

2: 99 percent / K₂CO₃ / acetone / 3 h / Heating

3: 95 percent / 4 M NaOH / tetrahydrofuran / 5 h / Heating

4: 72 percent / Br₂, aq. NaHCO₃ / CHCl₃ / 0.08 h / 0 °C

5: Et₃N / tetrahydrofuran / 0.33 h / 0 °C

6: NaBH₄ / H₂O / 0.67 h / 0 °C

7: 85 percent / i-Pr₂EtN / CH₂Cl₂ / 8 h / Ambient temperature

8: 93 percent / Zn, NH₄Cl / ethanol; H₂O / 1 h / 40 °C

9: 76 percent / DPPA, Et₃N, molecular sieves / 1.) room temperature, 1.5 h, 2.) reflux, 5 h

10: 73 percent / OsO₄, NaIO₄ / dioxane; H₂O / 13 h / Ambient temperature

11: 100 percent / NaBH₄ / ethanol / 0.67 h / Ambient temperature

12: 97 percent / Et₃N, DMAP / CH₂Cl₂ / 2 h / Ambient temperature

13: 1.) TBDMSOTf, Py, 2.) TBAF / 1.) CH₂Cl₂, room temperature, 4 h, 2.) THF, room temperature, 1 h

With pyridine; dmap; sodium hydroxide; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; molecular sieve; t-butyldimethylsiyl triflate; diphenyl-phosphinic acid; tetrabutyl ammonium fluoride; bromine; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; water; acetone;

DOI:10.1016/S0040-4020(97)00651-0

upstream raw materials:

{3-Benzyloxy-5-benzyloxymethoxymethyl-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-carbamic acid tert-butyl ester

Dimethyl 5-hydroxyisophthalate

5-Hydroxyisophthalic acid

dimethyl 5-(prop-2-en-1-yloxy)benzene-1,3-dicarboxylate

Downstream raw materials:

{3-Benzyloxy-5-benzyloxymethoxymethyl-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenyl}-carbamic acid allyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 177957-83-4 3-Benzyloxy-5-benzyloxymethoxymethyl-2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-phenylamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send