8-chloro-N-1-[(1R,2S,3R,4R)-2,3-isopropylidenedioxy-4-(hydroxymethyl)cyclopentyl]-5'-O-[bis(phenylthio)phosphoryl]-2',3'-O-isopropylideneadenosine

Base Information

Chemical Name:8-chloro-N-1-[(1R,2S,3R,4R)-2,3-isopropylidenedioxy-4-(hydroxymethyl)cyclopentyl]-5'-O-[bis(phenylthio)phosphoryl]-2',3'-O-isopropylideneadenosine
CAS No.:623547-33-1
Molecular Formula:C₃₄H₃₉ClN₅O₈PS₂
Molecular Weight:776.271
Hs Code.:

8-chloro-N-1-[(1R,2S,3R,4R)-2,3-isopropylidenedioxy-4-(hydroxymethyl)cyclopentyl]-5'-O-[bis(phenylthio)phosphoryl]-2',3'-O-isopropylideneadenosine

Synonyms:8-chloro-N-1-[(1R,2S,3R,4R)-2,3-isopropylidenedioxy-4-(hydroxymethyl)cyclopentyl]-5'-O-[bis(phenylthio)phosphoryl]-2',3'-O-isopropylideneadenosine

Suppliers and Price of 8-chloro-N-1-[(1R,2S,3R,4R)-2,3-isopropylidenedioxy-4-(hydroxymethyl)cyclopentyl]-5'-O-[bis(phenylthio)phosphoryl]-2',3'-O-isopropylideneadenosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 8-chloro-N-1-[(1R,2S,3R,4R)-2,3-isopropylidenedioxy-4-(hydroxymethyl)cyclopentyl]-5'-O-[bis(phenylthio)phosphoryl]-2',3'-O-isopropylideneadenosine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 8-chloro-N-1-[(1R,2S,3R,4R)-2,3-isopropylidenedioxy-4-(hydroxymethyl)cyclopentyl]-5'-O-[bis(phenylthio)phosphoryl]-2',3'-O-isopropylideneadenosine

There total 9 articles about 8-chloro-N-1-[(1R,2S,3R,4R)-2,3-isopropylidenedioxy-4-(hydroxymethyl)cyclopentyl]-5'-O-[bis(phenylthio)phosphoryl]-2',3'-O-isopropylideneadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 623547-32-0
8-chloro-N-1-[(1R,2S,3R,4R)-2,3-isopropylidenedioxy-4-[(5-monomethoxytrityl)oxymethyl]cyclopentyl]-5'-O-[bis(phenylthio)phosphoryl]-2',3'-O-isopropylideneadenosine

: 623547-33-1
8-chloro-N-1-[(1R,2S,3R,4R)-2,3-isopropylidenedioxy-4-(hydroxymethyl)cyclopentyl]-5'-O-[bis(phenylthio)phosphoryl]-2',3'-O-isopropylideneadenosine

Guidance literature:: With acetic acid; at 20 ℃; for 6h;
DOI:10.1021/jm030227f

Reference yield:

: 132342-52-0
((3aR,4R,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)methanol

: 623547-33-1
8-chloro-N-1-[(1R,2S,3R,4R)-2,3-isopropylidenedioxy-4-(hydroxymethyl)cyclopentyl]-5'-O-[bis(phenylthio)phosphoryl]-2',3'-O-isopropylideneadenosine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 89 percent / K₂CO₃ / dimethylformamide / 20 h / 20 °C

2.1: 79 percent / pyridine / 1.5 h / 20 °C

3.1: 88 percent / TBAF; AcOH / tetrahydrofuran / 1 h / 20 °C

4.1: TPSCl; pyridine / 2 h / 20 °C

4.2: 67 percent / pyridine / 2 h / 20 °C

5.1: 85 percent / aq. acetic acid / 6 h / 20 °C

With pyridine; Triphenylsilyl chloride; tetrabutyl ammonium fluoride; potassium carbonate; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm030227f

Reference yield:

: 5-amino-1-[5'-O-(tert-butyldimethylsilyl)-2',3-Oisopropylidene-β-D-ribofuranosyl]-1H-imidazole-4-carbonitrile

: 623547-33-1
8-chloro-N-1-[(1R,2S,3R,4R)-2,3-isopropylidenedioxy-4-(hydroxymethyl)cyclopentyl]-5'-O-[bis(phenylthio)phosphoryl]-2',3'-O-isopropylideneadenosine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 84 percent / N-chlorosuccinimide / tetrahydrofuran / 10.5 h / 20 °C

2.1: 95 percent / TFA / 0.17 h / 50 °C

3.1: 89 percent / K₂CO₃ / dimethylformamide / 20 h / 20 °C

4.1: 79 percent / pyridine / 1.5 h / 20 °C

5.1: 88 percent / TBAF; AcOH / tetrahydrofuran / 1 h / 20 °C

6.1: TPSCl; pyridine / 2 h / 20 °C

6.2: 67 percent / pyridine / 2 h / 20 °C

7.1: 85 percent / aq. acetic acid / 6 h / 20 °C

With pyridine; N-chloro-succinimide; Triphenylsilyl chloride; tetrabutyl ammonium fluoride; potassium carbonate; acetic acid; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm030227f