(nitro-5 thenylidene-2 amino)-4 (hydroxy-2 ethyl)-1 phenyl-3 triazol-1,2,4 one-5

Base Information

• Chemical Name: (nitro-5 thenylidene-2 amino)-4 (hydroxy-2 ethyl)-1 phenyl-3 triazol-1,2,4 one-5
• CAS No.: 87296-99-9
• Molecular Formula: C₁₅H₁₃N₅O₄S
• Molecular Weight: 359.365
• Mol file: 87296-99-9.mol

Synonyms:(nitro-5 thenylidene-2 amino)-4 (hydroxy-2 ethyl)-1 phenyl-3 triazol-1,2,4 one-5

Chemical Property of (nitro-5 thenylidene-2 amino)-4 (hydroxy-2 ethyl)-1 phenyl-3 triazol-1,2,4 one-5

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (nitro-5 thenylidene-2 amino)-4 (hydroxy-2 ethyl)-1 phenyl-3 triazol-1,2,4 one-5

There total 3 articles about (nitro-5 thenylidene-2 amino)-4 (hydroxy-2 ethyl)-1 phenyl-3 triazol-1,2,4 one-5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-nitrothiophene-2-carboxaldehyde diacetate (14289-24-8) + amino-4 (hydroxy-2 ethyl)-1 phenyl-3 triazol-1,2,4 one-5 (87296-97-7) → (nitro-5 thenylidene-2 amino)-4 (hydroxy-2 ethyl)-1 phenyl-3 triazol-1,2,4 one-5 (87296-99-9)

Guidance literature:

With hydrogenchloride; In propan-1-ol; for 4h; Heating;

Reference yield:

N'-[1-Ethoxy-1-phenyl-meth-(Z)-ylidene]-hydrazinecarboxylic acid ethyl ester (70249-85-3) → (nitro-5 thenylidene-2 amino)-4 (hydroxy-2 ethyl)-1 phenyl-3 triazol-1,2,4 one-5 (87296-99-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / NH₂NH₂*H₂O

2: 42 percent / NaH (80percent in paraffin oil) / dimethylformamide / 24 h / 70 - 80 °C

3: 80 percent / concd. HCl / propan-1-ol / 4 h / Heating

With hydrogenchloride; sodium hydride; hydrazine hydrate; In propan-1-ol; N,N-dimethyl-formamide;

Reference yield:

4-amino-5-phenyl-2,4-dihydro-[1,2,4]triazol-3-one (57735-10-1) → (nitro-5 thenylidene-2 amino)-4 (hydroxy-2 ethyl)-1 phenyl-3 triazol-1,2,4 one-5 (87296-99-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 42 percent / NaH (80percent in paraffin oil) / dimethylformamide / 24 h / 70 - 80 °C

2: 80 percent / concd. HCl / propan-1-ol / 4 h / Heating

With hydrogenchloride; sodium hydride; In propan-1-ol; N,N-dimethyl-formamide;

upstream raw materials:

5-nitrothiophene-2-carboxaldehyde diacetate

amino-4 (hydroxy-2 ethyl)-1 phenyl-3 triazol-1,2,4 one-5

N'-[1-Ethoxy-1-phenyl-meth-(Z)-ylidene]-hydrazinecarboxylic acid ethyl ester

4-amino-5-phenyl-2,4-dihydro-[1,2,4]triazol-3-one