1,2,3,4-tetrahydro-2,2-dimethyl-1-[[2-(phenylethynyl)phenyl]ethynyl]-1-naphthalenol

Base Information

• Chemical Name: 1,2,3,4-tetrahydro-2,2-dimethyl-1-[[2-(phenylethynyl)phenyl]ethynyl]-1-naphthalenol
• CAS No.: 372967-83-4
• Molecular Formula: C₂₈H₂₄O
• Molecular Weight: 376.498
• Mol file: 372967-83-4.mol

Synonyms:1,2,3,4-tetrahydro-2,2-dimethyl-1-[[2-(phenylethynyl)phenyl]ethynyl]-1-naphthalenol

Chemical Property of 1,2,3,4-tetrahydro-2,2-dimethyl-1-[[2-(phenylethynyl)phenyl]ethynyl]-1-naphthalenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2,3,4-tetrahydro-2,2-dimethyl-1-[[2-(phenylethynyl)phenyl]ethynyl]-1-naphthalenol

There total 1 articles about 1,2,3,4-tetrahydro-2,2-dimethyl-1-[[2-(phenylethynyl)phenyl]ethynyl]-1-naphthalenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,2-dimethyl-3,4-dihydro-2H-naphthalen-1-one (2977-45-9) + 2-(phenylethynyl)phenylacetylene (143192-60-3) → 1,2,3,4-tetrahydro-2,2-dimethyl-1-[[2-(phenylethynyl)phenyl]ethynyl]-1-naphthalenol (372967-83-4)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;

DOI:10.1021/jo0104577

Reference yield: 98.0%

1,2,3,4-tetrahydro-2,2-dimethyl-1-[[2-(phenylethynyl)phenyl]ethynyl]-1-naphthalenol (372967-83-4) → 2,2-dimethyl-1-(2-phenylethynyl-phenylethynyl)-1,2,3,4-tetrahydro-naphthalene (372967-91-4)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1021/jo0104577

Reference yield: 32.0%

1,2,3,4-tetrahydro-2,2-dimethyl-1-[[2-(phenylethynyl)phenyl]ethynyl]-1-naphthalenol (372967-83-4) → C28H23Cl + 1,1-dimethyl-7-phenyl-1,2,3,12-tetrahydro-indeno[2,1-a]phenalen-12-ol

Guidance literature:

1,2,3,4-tetrahydro-2,2-dimethyl-1-[[2-(phenylethynyl)phenyl]ethynyl]-1-naphthalenol; With thionyl chloride; In pyridine; diethyl ether; at 0 - 20 ℃; for 4h;

With water; silica gel;

DOI:10.1021/jo0104577

upstream raw materials:

2,2-dimethyl-3,4-dihydro-2H-naphthalen-1-one

2-(phenylethynyl)phenylacetylene

Downstream raw materials:

2,2-dimethyl-1-(2-phenylethynyl-phenylethynyl)-1,2,3,4-tetrahydro-naphthalene