(2S,3S,5aS,10aS)-6'-methoxy-3-phenyl-5a,6,7,8-tetrahydro-1H-spiro[dipyrrolo[1,2-a:1'2'-d]pyrazine-2,3'-indoline]-2',5,10(3H,10aH)-trione

Base Information

Chemical Name:(2S,3S,5aS,10aS)-6'-methoxy-3-phenyl-5a,6,7,8-tetrahydro-1H-spiro[dipyrrolo[1,2-a:1'2'-d]pyrazine-2,3'-indoline]-2',5,10(3H,10aH)-trione
CAS No.:1318074-96-2
Molecular Formula:C₂₄H₂₃N₃O₄
Molecular Weight:417.464
Hs Code.:

Synonyms:(2S,3S,5aS,10aS)-6'-methoxy-3-phenyl-5a,6,7,8-tetrahydro-1H-spiro[dipyrrolo[1,2-a:1'2'-d]pyrazine-2,3'-indoline]-2',5,10(3H,10aH)-trione

Suppliers and Price of (2S,3S,5aS,10aS)-6'-methoxy-3-phenyl-5a,6,7,8-tetrahydro-1H-spiro[dipyrrolo[1,2-a:1'2'-d]pyrazine-2,3'-indoline]-2',5,10(3H,10aH)-trione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3S,5aS,10aS)-6'-methoxy-3-phenyl-5a,6,7,8-tetrahydro-1H-spiro[dipyrrolo[1,2-a:1'2'-d]pyrazine-2,3'-indoline]-2',5,10(3H,10aH)-trione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3S,5aS,10aS)-6'-methoxy-3-phenyl-5a,6,7,8-tetrahydro-1H-spiro[dipyrrolo[1,2-a:1'2'-d]pyrazine-2,3'-indoline]-2',5,10(3H,10aH)-trione

There total 16 articles about (2S,3S,5aS,10aS)-6'-methoxy-3-phenyl-5a,6,7,8-tetrahydro-1H-spiro[dipyrrolo[1,2-a:1'2'-d]pyrazine-2,3'-indoline]-2',5,10(3H,10aH)-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1318074-92-8
(2'S,5'S,3S)-6-methoxy-2-oxo-2'-phenyl-1'-[1-(3,3,3-trichloroethoxycarbonyl)-pyrrolidine-2S-carbonyl]-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid methyl ester

: 1318074-96-2
(2S,3S,5aS,10aS)-6'-methoxy-3-phenyl-5a,6,7,8-tetrahydro-1H-spiro[dipyrrolo[1,2-a:1'2'-d]pyrazine-2,3'-indoline]-2',5,10(3H,10aH)-trione

Guidance literature:: With ammonium chloride; zinc; In tetrahydrofuran; methanol; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1039/c1ob05710c

Reference yield:

: 1318074-51-9
6-methoxy-3-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecylsulfanyl)-1-(2,4-dimethoxybenzyl)-1,3-dihydroindol-2-one

: 1318074-96-2
(2S,3S,5aS,10aS)-6'-methoxy-3-phenyl-5a,6,7,8-tetrahydro-1H-spiro[dipyrrolo[1,2-a:1'2'-d]pyrazine-2,3'-indoline]-2',5,10(3H,10aH)-trione

Guidance literature:: Multi-step reaction with 10 steps

1.1: methoxybenzene; trifluoroacetic acid / dichloromethane / 48 h / 50 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 20 °C / Inert atmosphere

3.1: samarium diiodide / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

3.2: 80 °C / Inert atmosphere; Sealed tube

4.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone; tert-butyl alcohol / 48 h / 20 °C / Inert atmosphere

5.1: lead(IV) tetraacetate / ethyl acetate / 0.25 h / 20 °C / Inert atmosphere

6.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; acetonitrile; tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

7.1: methanol; hexane / 2 h / 20 °C / Inert atmosphere

8.1: hydrogenchloride; hydrogen; palladium(II) hydroxide / methanol; water / 0.08 h / 760.05 Torr / Inert atmosphere

9.1: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere; Resolution of racemate

10.1: ammonium chloride; zinc / tetrahydrofuran; methanol / 24 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; osmium(VIII) oxide; samarium diiodide; 2-methyl-but-2-ene; hydrogen; lead(IV) tetraacetate; palladium(II) hydroxide; potassium carbonate; ammonium chloride; methoxybenzene; 4-methylmorpholine N-oxide; triethylamine; trifluoroacetic acid; zinc; In tetrahydrofuran; methanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol;
DOI:10.1039/c1ob05710c

Reference yield:

: 1318074-58-6
6-methoxy-3-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecylsulfanyl)-1,3-dihydroindol-2-one

: 1318074-96-2
(2S,3S,5aS,10aS)-6'-methoxy-3-phenyl-5a,6,7,8-tetrahydro-1H-spiro[dipyrrolo[1,2-a:1'2'-d]pyrazine-2,3'-indoline]-2',5,10(3H,10aH)-trione

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.75 h / 20 °C / Inert atmosphere

2.1: samarium diiodide / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

2.2: 80 °C / Inert atmosphere; Sealed tube

3.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetone; tert-butyl alcohol / 48 h / 20 °C / Inert atmosphere

4.1: lead(IV) tetraacetate / ethyl acetate / 0.25 h / 20 °C / Inert atmosphere

5.1: sodium dihydrogenphosphate; sodium chlorite; 2-methyl-but-2-ene / water; acetonitrile; tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

6.1: methanol; hexane / 2 h / 20 °C / Inert atmosphere

7.1: hydrogenchloride; hydrogen; palladium(II) hydroxide / methanol; water / 0.08 h / 760.05 Torr / Inert atmosphere

8.1: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere; Resolution of racemate

9.1: ammonium chloride; zinc / tetrahydrofuran; methanol / 24 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; osmium(VIII) oxide; samarium diiodide; 2-methyl-but-2-ene; hydrogen; lead(IV) tetraacetate; palladium(II) hydroxide; potassium carbonate; ammonium chloride; 4-methylmorpholine N-oxide; triethylamine; zinc; In tetrahydrofuran; methanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; acetonitrile; tert-butyl alcohol;
DOI:10.1039/c1ob05710c