Technology Process of 3-(tert-butyl-diphenyl-silanyloxymethyl)-5-hexyl-decahydro-pyrrolo[2,1-j]quinoline
There total 16 articles about 3-(tert-butyl-diphenyl-silanyloxymethyl)-5-hexyl-decahydro-pyrrolo[2,1-j]quinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C36H47NO3Si;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at -78 - 20 ℃;
With
hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol;
at 20 ℃;
for 24h;
under 3102.89 Torr;
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: pyridinium p-toluenesulfonate / methanol / 1 h / Heating
2.1: imidazole / CH2Cl2 / 20 °C
3.1: 12.0 g / DIBAL-H / CH2Cl2 / -78 - 0 °C
4.1: pyridine / 20 °C
5.1: 100 percent / TFA / CH2Cl2 / 1 h / 0 °C
6.1: 61 percent / pyridine / ethanol / 48 h / Heating
7.1: K2CO3 / methanol; H2O / 1 h / 20 °C
8.1: 504.0 mg / N-methylmorpholine-N-oxide; TPAP; 4 Angstroem molecular sieves / CH2Cl2 / 1 h / 20 °C
9.1: Na2SO4; piperidinium acetate / ethyl acetate; toluene / Heating
10.1: 91 percent / H2 / 10 percent Pd/C / methanol / 24 h / 20 °C / 760 Torr
11.1: LiAlH4 / tetrahydrofuran / -78 - 20 °C
11.2: 21 percent / H2 / 25 percent Pd/C / tetrahydrofuran; ethanol / 24 h / 20 °C / 3102.89 Torr
With
pyridine; 1H-imidazole; lithium aluminium tetrahydride; tetrapropylammonium perruthennate; 4 A molecular sieve; hydrogen; pyridinium p-toluenesulfonate; piperdinium acetate; diisobutylaluminium hydride; potassium carbonate; 4-methylmorpholine N-oxide; sodium sulfate; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 61 percent / pyridine / ethanol / 48 h / Heating
2.1: K2CO3 / methanol; H2O / 1 h / 20 °C
3.1: 504.0 mg / N-methylmorpholine-N-oxide; TPAP; 4 Angstroem molecular sieves / CH2Cl2 / 1 h / 20 °C
4.1: Na2SO4; piperidinium acetate / ethyl acetate; toluene / Heating
5.1: 91 percent / H2 / 10 percent Pd/C / methanol / 24 h / 20 °C / 760 Torr
6.1: LiAlH4 / tetrahydrofuran / -78 - 20 °C
6.2: 21 percent / H2 / 25 percent Pd/C / tetrahydrofuran; ethanol / 24 h / 20 °C / 3102.89 Torr
With
pyridine; lithium aluminium tetrahydride; tetrapropylammonium perruthennate; 4 A molecular sieve; hydrogen; piperdinium acetate; potassium carbonate; 4-methylmorpholine N-oxide; sodium sulfate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; toluene;
