2-(3-{5-[(1R,2S)-1-Ethyl-2-(4-hydroxy-phenyl)-butyl]-2-hydroxy-phenyl}-propyl)-4-nitro-isoindole-1,3-dione

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Chemical Name:2-(3-{5-[(1R,2S)-1-Ethyl-2-(4-hydroxy-phenyl)-butyl]-2-hydroxy-phenyl}-propyl)-4-nitro-isoindole-1,3-dione
CAS No.:104946-93-2
Molecular Formula:C₂₉H₃₀N₂O₆
Molecular Weight:502.567
Hs Code.:

Synonyms:2-(3-{5-[(1R,2S)-1-Ethyl-2-(4-hydroxy-phenyl)-butyl]-2-hydroxy-phenyl}-propyl)-4-nitro-isoindole-1,3-dione

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Chemical Property of 2-(3-{5-[(1R,2S)-1-Ethyl-2-(4-hydroxy-phenyl)-butyl]-2-hydroxy-phenyl}-propyl)-4-nitro-isoindole-1,3-dione

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Technology Process of 2-(3-{5-[(1R,2S)-1-Ethyl-2-(4-hydroxy-phenyl)-butyl]-2-hydroxy-phenyl}-propyl)-4-nitro-isoindole-1,3-dione

There total 4 articles about 2-(3-{5-[(1R,2S)-1-Ethyl-2-(4-hydroxy-phenyl)-butyl]-2-hydroxy-phenyl}-propyl)-4-nitro-isoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 641-70-3
3-nitrophthalic acid anhydride

: 104946-86-3
(3R*,4S*)-3-<3-(3-aminopropyl)-4-(2-tetrahydropyranyloxy)phenyl>-4-<4-(2-tetrahydropyranyloxy)phenyl>hexane

: 104946-93-2
2-(3-{5-[(1R,2S)-1-Ethyl-2-(4-hydroxy-phenyl)-butyl]-2-hydroxy-phenyl}-propyl)-4-nitro-isoindole-1,3-dione

Guidance literature:: With acetic acid; for 3h; Heating;
DOI:10.1021/jm00384a026

Reference yield:

: 104946-83-0
3-[5-{(1R,2S)-1-Ethyl-2-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-butyl}-2-(tetrahydro-pyran-2-yloxy)-phenyl]-propan-1-ol

: 104946-93-2
2-(3-{5-[(1R,2S)-1-Ethyl-2-(4-hydroxy-phenyl)-butyl]-2-hydroxy-phenyl}-propyl)-4-nitro-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / pyridine / 8 h / 0 °C

2: 90 percent / dimethylformamide / 3 h / 70 °C

3: 100 percent / hydrazine hydrate / ethanol / 48 h / 25 °C

4: 82 percent / AcOH / 3 h / Heating

With pyridine; hydrazine hydrate; acetic acid; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00384a026

Reference yield:

: 104946-85-2
(3R*,4S*)-3-<3-(3-phthalimidopropyl)-4-(2-tetrahydropyranyloxy)phenyl>-4-<4-(2-tetrahydropyranyloxy)phenyl>hexane

: 104946-93-2
2-(3-{5-[(1R,2S)-1-Ethyl-2-(4-hydroxy-phenyl)-butyl]-2-hydroxy-phenyl}-propyl)-4-nitro-isoindole-1,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / hydrazine hydrate / ethanol / 48 h / 25 °C

2: 82 percent / AcOH / 3 h / Heating

With hydrazine hydrate; acetic acid; In ethanol;
DOI:10.1021/jm00384a026