thiophen-2-ylmethyl-[3-(4-trifluoromethoxybenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo-[1,5-a]pyrimidin-5-yl]amine

Base Information

Chemical Name:thiophen-2-ylmethyl-[3-(4-trifluoromethoxybenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo-[1,5-a]pyrimidin-5-yl]amine
CAS No.:1383563-62-9
Molecular Formula:C₁₉H₁₂F₃N₅O₃S₃
Molecular Weight:511.529
Hs Code.:

Synonyms:thiophen-2-ylmethyl-[3-(4-trifluoromethoxybenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo-[1,5-a]pyrimidin-5-yl]amine

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Chemical Property of thiophen-2-ylmethyl-[3-(4-trifluoromethoxybenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo-[1,5-a]pyrimidin-5-yl]amine

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Technology Process of thiophen-2-ylmethyl-[3-(4-trifluoromethoxybenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo-[1,5-a]pyrimidin-5-yl]amine

There total 8 articles about thiophen-2-ylmethyl-[3-(4-trifluoromethoxybenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo-[1,5-a]pyrimidin-5-yl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 27757-85-3
2-Aminomethylthiophene

: 1383563-56-1
3-(4-trifluoromethoxybenzenesulfonyl)-4H-thieno[2,3-e]-[1,2,3]triazolo[1,5-a]pyrimidin-5-one

: 1383563-62-9
thiophen-2-ylmethyl-[3-(4-trifluoromethoxybenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo-[1,5-a]pyrimidin-5-yl]amine

Guidance literature:: 2-Aminomethylthiophene; 3-(4-trifluoromethoxybenzenesulfonyl)-4H-thieno[2,3-e]-[1,2,3]triazolo[1,5-a]pyrimidin-5-one; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 100 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; In water; at 20 ℃; for 0.5h;
DOI:10.1021/jm300491y

Reference yield: 2.0%

: 1383563-62-9
thiophen-2-ylmethyl-[3-(4-trifluoromethoxybenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo-[1,5-a]pyrimidin-5-yl]amine

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 930-96-1
3-bromo-2-thiophenecarboxaldehyde

: 1383563-62-9
thiophen-2-ylmethyl-[3-(4-trifluoromethoxybenzenesulfonyl)thieno[2,3-e][1,2,3]triazolo-[1,5-a]pyrimidin-5-yl]amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium azide / dimethyl sulfoxide / 48 h / 65 °C

2.1: sodium chlorite; aminosulfonic acid / water; acetone / 0.5 h / 0 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere

4.1: sodium ethanolate / ethanol / 0.25 h / 20 °C

4.2: 0.5 h / 20 °C

5.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 100 °C / Microwave irradiation

5.2: 0.5 h / 20 °C

With sodium chlorite; sodium azide; aminosulfonic acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium ethanolate; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jm300491y