(Z)-(2-amino-5-(2-(thiophen-2-yl)vinyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

Base Information

Chemical Name:(Z)-(2-amino-5-(2-(thiophen-2-yl)vinyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone
CAS No.:1309872-62-5
Molecular Formula:C₂₀H₁₉NO₄S₂
Molecular Weight:401.507
Hs Code.:

Synonyms:(Z)-(2-amino-5-(2-(thiophen-2-yl)vinyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

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Chemical Property of (Z)-(2-amino-5-(2-(thiophen-2-yl)vinyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

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Technology Process of (Z)-(2-amino-5-(2-(thiophen-2-yl)vinyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

There total 6 articles about (Z)-(2-amino-5-(2-(thiophen-2-yl)vinyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1309872-58-9
(2-amino-5-(2-(thiophen-2-yl)ethynyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

: 1309872-62-5
(Z)-(2-amino-5-(2-(thiophen-2-yl)vinyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: With hydrogen; In ethanol; for 18h; under 2068.65 Torr; Inert atmosphere;
DOI:10.1016/j.bmcl.2010.11.083

Reference yield:

: 901118-27-2
(2-amino-thiophen-3-yl)-(3,4,5-trimethoxy-phenyl)-methanone

: 1309872-62-5
(Z)-(2-amino-5-(2-(thiophen-2-yl)vinyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / Inert atmosphere

2: bromine; sodium acetate; acetic acid / 20 °C / Inert atmosphere

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

4: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

5: hydrogen / ethanol / 18 h / 2068.65 Torr / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; bromine; sodium acetate; hydrazine hydrate; acetic acid; triethylamine; In ethanol; N,N-dimethyl-formamide; 3: Sonogashira cross-coupling;
DOI:10.1016/j.bmcl.2010.11.083

Reference yield:

: 901118-49-8
2-[3-(3,4,5-trimethoxybenzoyl)thiophen-2-yl]isoindole-1,3-dione

: 1309872-62-5
(Z)-(2-amino-5-(2-(thiophen-2-yl)vinyl)thiophen-3-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: bromine; sodium acetate; acetic acid / 20 °C / Inert atmosphere

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

3: hydrazine hydrate / ethanol / 3 h / Inert atmosphere; Reflux

4: hydrogen / ethanol / 18 h / 2068.65 Torr / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; bromine; sodium acetate; hydrazine hydrate; acetic acid; triethylamine; In ethanol; N,N-dimethyl-formamide; 2: Sonogashira cross-coupling;
DOI:10.1016/j.bmcl.2010.11.083