ethyl 3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylate

Base Information

• Chemical Name: ethyl 3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylate
• CAS No.: 296262-43-6
• Molecular Formula: C₁₅H₁₄N₂O₂S
• Molecular Weight: 286.354
• Mol file: 296262-43-6.mol

Synonyms:ethyl 3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylate

Chemical Property of ethyl 3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Ethyl3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylate

There total 2 articles about ethyl 3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole (947-95-5) + ethyl 2-sulfanylacetate (623-51-8) → ethyl 3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylate (296262-43-6)

Guidance literature:

With sodium; In ethanol; at 0 ℃; Reflux;

DOI:10.1002/jhet.1584

Reference yield: 71.0%

C12H12N2OS + potassium ethyl thioglycolate → ethyl 3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylate (296262-43-6)

Guidance literature:

With potassium carbonate; In ethanol; at 80 ℃; for 1h; Reflux;

DOI:10.1016/j.tetlet.2016.01.055

Reference yield: 76.0%

ethyl 3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxylate (296262-43-6) → 3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carbohydrazide (326916-95-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Reflux;

DOI:10.1002/jhet.1584

upstream raw materials:

5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole

ethyl 2-sulfanylacetate

Downstream raw materials:

3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carbohydrazide