ethyl 6-(3-hydroxyphenyl)-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

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Chemical Name:ethyl 6-(3-hydroxyphenyl)-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate
CAS No.:1446115-45-2
Molecular Formula:C₂₁H₁₈N₄O₃
Molecular Weight:374.399
Hs Code.:

Synonyms:ethyl 6-(3-hydroxyphenyl)-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

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Chemical Property of ethyl 6-(3-hydroxyphenyl)-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

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Technology Process of ethyl 6-(3-hydroxyphenyl)-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

There total 5 articles about ethyl 6-(3-hydroxyphenyl)-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1227077-01-1
ethyl 6-oxo-1-(pyridin-4-ylmethyl)-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

: 87199-18-6
3-hydroxyphenylboronic acid

: 1446115-45-2
ethyl 6-(3-hydroxyphenyl)-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

Guidance literature:: ethyl 6-oxo-1-(pyridin-4-ylmethyl)-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-4-carboxylate; With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; at 20 ℃; for 2h;

3-hydroxyphenylboronic acid; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 100 ℃; for 4h;
DOI:10.1021/jm301709s

Reference yield:

: 872-85-5
pyridine-4-carbaldehyde

: 1446115-45-2
ethyl 6-(3-hydroxyphenyl)-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / ethanol / 24 h / 0 - 20 °C

1.2: 2 h / 20 °C

2.1: sodium butanolate / butan-1-ol / 120 °C

3.1: benzene / 15 h / 65 °C

4.1: acetic acid / 4 h / Reflux

5.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; triethylamine / 1,4-dioxane / 2 h / 20 °C

5.2: 4 h / 100 °C

With hydrazine hydrate; acetic acid; triethylamine; sodium butanolate; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; ethanol; butan-1-ol; benzene; 5.2: |Suzuki Coupling;
DOI:10.1021/jm301709s

Reference yield:

: 329264-80-4
C₉H₁₀N₄

: 1446115-45-2
ethyl 6-(3-hydroxyphenyl)-1-(pyridin-4-ylmethyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium butanolate / butan-1-ol / 120 °C

2.1: benzene / 15 h / 65 °C

3.1: acetic acid / 4 h / Reflux

4.1: bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; triethylamine / 1,4-dioxane / 2 h / 20 °C

4.2: 4 h / 100 °C

With acetic acid; triethylamine; sodium butanolate; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; butan-1-ol; benzene; 4.2: |Suzuki Coupling;
DOI:10.1021/jm301709s