methyl (4aR)-3-[(2-bromo-5,5-dimethyl-1-cyclohexen-1-yl)methyl]-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate

Base Information

Chemical Name:methyl (4aR)-3-[(2-bromo-5,5-dimethyl-1-cyclohexen-1-yl)methyl]-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate
CAS No.:1053265-71-6
Molecular Formula:C₂₃H₃₁BrN₂O₂
Molecular Weight:447.415
Hs Code.:

Synonyms:methyl (4aR)-3-[(2-bromo-5,5-dimethyl-1-cyclohexen-1-yl)methyl]-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate

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Chemical Property of methyl (4aR)-3-[(2-bromo-5,5-dimethyl-1-cyclohexen-1-yl)methyl]-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate

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Technology Process of methyl (4aR)-3-[(2-bromo-5,5-dimethyl-1-cyclohexen-1-yl)methyl]-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate

There total 4 articles about methyl (4aR)-3-[(2-bromo-5,5-dimethyl-1-cyclohexen-1-yl)methyl]-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1053265-65-8
1-bromo-2-(bromomethyl)-4,4-dimethylcyclohex-1-ene

: 1053265-69-2
methyl (4aR)-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate

: 1053265-71-6
methyl (4aR)-3-[(2-bromo-5,5-dimethyl-1-cyclohexen-1-yl)methyl]-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate

Guidance literature:: With triethylamine; sodium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

Reference yield:

: 1073-13-8
4,4-dimethylcyclohexenone

: 1053265-71-6
methyl (4aR)-3-[(2-bromo-5,5-dimethyl-1-cyclohexen-1-yl)methyl]-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate / 2 h / 20 °C / 760.05 Torr

2.1: phosphorus tribromide / dichloromethane / 0.5 h / 0 - 20 °C

2.2: 4 h / 0 - 20 °C

3.1: sodium tetrahydroborate / methanol / 5 h / 0 - 20 °C

4.1: phosphorus tribromide / diethyl ether / 1.5 h / 0 °C

5.1: triethylamine; sodium iodide / N,N-dimethyl-formamide / 3 h / 80 °C

With sodium tetrahydroborate; hydrogen; phosphorus tribromide; triethylamine; sodium iodide; 5%-palladium/activated carbon; In methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1053265-67-0
(2-bromo-5,5-dimethyl-1-cyclohexen-1-yl)-methanol

: 1053265-71-6
methyl (4aR)-3-[(2-bromo-5,5-dimethyl-1-cyclohexen-1-yl)methyl]-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus tribromide / diethyl ether / 1.5 h / 0 °C

2: triethylamine; sodium iodide / N,N-dimethyl-formamide / 3 h / 80 °C

With phosphorus tribromide; triethylamine; sodium iodide; In diethyl ether; N,N-dimethyl-formamide;