17-chloro-3,3-<1,2-ethanediylbis(oxy)>-17aα-(1-propynyl)-11β-<4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-17a-homo-5α-estr-16-en-5,17aβ-diol

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Chemical Name:17-chloro-3,3-<1,2-ethanediylbis(oxy)>-17aα-(1-propynyl)-11β-<4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-17a-homo-5α-estr-16-en-5,17aβ-diol
CAS No.:143611-09-0
Molecular Formula:C₃₁H₃₆ClF₃O₇S
Molecular Weight:645.137
Hs Code.:

Synonyms:17-chloro-3,3-<1,2-ethanediylbis(oxy)>-17aα-(1-propynyl)-11β-<4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-17a-homo-5α-estr-16-en-5,17aβ-diol

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Chemical Property of 17-chloro-3,3-<1,2-ethanediylbis(oxy)>-17aα-(1-propynyl)-11β-<4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-17a-homo-5α-estr-16-en-5,17aβ-diol

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Technology Process of 17-chloro-3,3-<1,2-ethanediylbis(oxy)>-17aα-(1-propynyl)-11β-<4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-17a-homo-5α-estr-16-en-5,17aβ-diol

There total 1 articles about 17-chloro-3,3-<1,2-ethanediylbis(oxy)>-17aα-(1-propynyl)-11β-<4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-17a-homo-5α-estr-16-en-5,17aβ-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 74-99-7
prop-1-yne

: 143611-09-0
17-chloro-3,3-<1,2-ethanediylbis(oxy)>-17aα-(1-propynyl)-11β-<4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-17a-homo-5α-estr-16-en-5,17aβ-diol

Guidance literature:: With dmap; In dichloromethane; for 1.5h;
DOI:10.1016/0039-128X(94)90024-8

Reference yield:

: 143611-09-0
17-chloro-3,3-<1,2-ethanediylbis(oxy)>-17aα-(1-propynyl)-11β-<4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-17a-homo-5α-estr-16-en-5,17aβ-diol

: 11β-(4-acetylphenyl)-17-chloro-17aβ-hydroxy-17aα-(1-propynyl)-17a-homoestra-4,16-dien-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine)palladium⁽⁰⁾, LiCl, pyridine / dioxane / 2 h / Heating

2: 2 N aq. HCl / acetone / 0.33 h / 40 °C

With pyridine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; In 1,4-dioxane; acetone;
DOI:10.1016/0039-128X(94)90024-8

Reference yield:

: 143611-09-0
17-chloro-3,3-<1,2-ethanediylbis(oxy)>-17aα-(1-propynyl)-11β-<4-<<(trifluoromethyl)sulfonyl>oxy>phenyl>-17a-homo-5α-estr-16-en-5,17aβ-diol

: 17-chloro-17aβ-hydroxy-17aα-(1-propynyl)-11β-<4-(3-pyridinyl)phenyl>-17a-homo-estra-4,16-dien-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine)palladium⁽⁰⁾, LiCl, 2 N aq. NaHCO₃ / toluene; ethanol / 1 h / Heating

2: 2 N aq. HCl / acetone / 0.33 h / 40 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; lithium chloride; In ethanol; acetone; toluene;
DOI:10.1016/0039-128X(94)90024-8