C₆₅H₁₁₀O₁₂Si₂

Base Information

Chemical Name:C₆₅H₁₁₀O₁₂Si₂
CAS No.:216670-06-3
Molecular Formula:C₆₅H₁₁₀O₁₂Si₂
Molecular Weight:1139.75
Hs Code.:

C<sub>65</sub>H<sub>110</sub>O<sub>12</sub>Si<sub>2</sub>

Synonyms:C₆₅H₁₁₀O₁₂Si₂

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Chemical Property of C₆₅H₁₁₀O₁₂Si₂

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Technology Process of C₆₅H₁₁₀O₁₂Si₂

There total 14 articles about C₆₅H₁₁₀O₁₂Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 216669-99-7
(8Z,13Z,21Z)-(2R,3S,4R,5S,7S,10S,11S,12S,16S,17R,18S,19S,20S)-5-(tert-Butyl-dimethyl-silanyloxy)-3,17-bis-(4-methoxy-benzyloxy)-7,11-bis-methoxymethoxy-2,4,10,12,14,16,18,20-octamethyl-19-triethylsilanyloxy-tetracosa-8,13,21,23-tetraenoic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: 216670-06-3
C₆₅H₁₁₀O₁₂Si₂

Guidance literature:: In methanol; benzene; for 0.25h;
DOI:10.1021/jo9811423

Reference yield:

: 216668-18-7
(2S,3S,4S)-2,4-Dimethyl-1-triethylsilanyloxy-hex-5-yn-3-ol

: 216670-06-3
C₆₅H₁₁₀O₁₂Si₂

Guidance literature:: Multi-step reaction with 12 steps

1: 94 percent / N,N-diisopropylethylamine, tetrabutylammonium iodide / CH₂Cl₂ / 18 h / Ambient temperature

2: 1.) BuLi, 4 Angstroem molecular sieves, 2.) LiBr / 1) THF, hexane, -50 to -40 deg C, 1 h; 2) THF, hexane, -40 deg C, 15 min; 3) THF, hexane, -50 to -40 deg C, 1 h, -40 deg C, 1.5 h

3: H₂ / Pd/CaCO₃ / 24 h

4: 95 percent / N,N-diisopropylethylamine, tetrabutylammonium iodide / CH₂Cl₂ / 19 h / Ambient temperature

5: 99 percent / HF*pyridine / pyridine; tetrahydrofuran / 3.5 h

6: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.58 h

7: tetrahydrofuran; hexane / 1) -78 deg C, 5 min; 2) rt, 2.5 h

8: 1.) t-BuLi, 2.) 9-methoxy-9-borabicyclo<3.3.1>nonane, 3.) PdCl₂(dppf), aq. K₃PO₄ / 1) Et₂O, pentane, -78 deg C, 3 min; 2) Et₂O, pentane, hexane, THF, -78 deg C, 10 min, -78 deg C --> rt, 1.25 h; 3) Et₂O, pentane, THF, hexane, FMF, rt, 16 h

9: 79 percent / diisobutylaluminum hydride / CH₂Cl₂; hexane / 18 h / -50 °C

10: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h

11: 98 percent / aq. NaClO₂, NaH₂PO₄*H₂O, 2-methyl-2-butene / 2-methyl-propan-2-ol / 2 h / Ambient temperature

12: 82 percent / benzene; methanol / 0.25 h

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; 4 A molecular sieve; hydrogen; tert.-butyl lithium; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; Dess-Martin periodane; pyridine hydrogenfluoride; N-ethyl-N,N-diisopropylamine; 9-methoxy-9-BBN; lithium bromide; Lindlar's catalyst; In tetrahydrofuran; pyridine; methanol; hexane; dichloromethane; tert-butyl alcohol; benzene;
DOI:10.1021/jo9811423

Reference yield:

: 216668-26-7
Triethyl-((2S,3S,4S)-3-methoxymethoxy-2,4-dimethyl-hex-5-ynyloxy)-silane

: 216670-06-3
C₆₅H₁₁₀O₁₂Si₂

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) BuLi, 4 Angstroem molecular sieves, 2.) LiBr / 1) THF, hexane, -50 to -40 deg C, 1 h; 2) THF, hexane, -40 deg C, 15 min; 3) THF, hexane, -50 to -40 deg C, 1 h, -40 deg C, 1.5 h

2: H₂ / Pd/CaCO₃ / 24 h

3: 95 percent / N,N-diisopropylethylamine, tetrabutylammonium iodide / CH₂Cl₂ / 19 h / Ambient temperature

4: 99 percent / HF*pyridine / pyridine; tetrahydrofuran / 3.5 h

5: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.58 h

6: tetrahydrofuran; hexane / 1) -78 deg C, 5 min; 2) rt, 2.5 h

7: 1.) t-BuLi, 2.) 9-methoxy-9-borabicyclo<3.3.1>nonane, 3.) PdCl₂(dppf), aq. K₃PO₄ / 1) Et₂O, pentane, -78 deg C, 3 min; 2) Et₂O, pentane, hexane, THF, -78 deg C, 10 min, -78 deg C --> rt, 1.25 h; 3) Et₂O, pentane, THF, hexane, FMF, rt, 16 h

8: 79 percent / diisobutylaluminum hydride / CH₂Cl₂; hexane / 18 h / -50 °C

9: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h

10: 98 percent / aq. NaClO₂, NaH₂PO₄*H₂O, 2-methyl-2-butene / 2-methyl-propan-2-ol / 2 h / Ambient temperature

11: 82 percent / benzene; methanol / 0.25 h

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; 4 A molecular sieve; hydrogen; tert.-butyl lithium; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; Dess-Martin periodane; pyridine hydrogenfluoride; N-ethyl-N,N-diisopropylamine; 9-methoxy-9-BBN; lithium bromide; Lindlar's catalyst; In tetrahydrofuran; pyridine; methanol; hexane; dichloromethane; tert-butyl alcohol; benzene;
DOI:10.1021/jo9811423