methyl 3-[2-ethyl-5-(2-{[3-fluoro-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]benzoate

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Chemical Name:methyl 3-[2-ethyl-5-(2-{[3-fluoro-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]benzoate
CAS No.:1126431-92-2
Molecular Formula:C₂₇H₂₆FN₅O₃S
Molecular Weight:519.6
Hs Code.:

Synonyms:methyl 3-[2-ethyl-5-(2-{[3-fluoro-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]benzoate

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Chemical Property of methyl 3-[2-ethyl-5-(2-{[3-fluoro-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]benzoate

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Technology Process of methyl 3-[2-ethyl-5-(2-{[3-fluoro-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]benzoate

There total 1 articles about methyl 3-[2-ethyl-5-(2-{[3-fluoro-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1126431-91-1
methyl 3-[5-(2-chloro-4-pyrimidinyl)-2-ethyl-1,3-thiazol-4-yl]benzoate

: 93246-53-8
3-fluoro-4-(morpholinyl)aniline

: 1126431-92-2
methyl 3-[2-ethyl-5-(2-{[3-fluoro-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]benzoate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; 2,2,2-trifluoroethanol; at 170 ℃; for 0.333333h; Microwave irradiation;

Reference yield: 25.0%

: 1126431-92-2
methyl 3-[2-ethyl-5-(2-{[3-fluoro-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]benzoate

: 1126431-90-0
{3-[2-ethyl-5-(2-{[3-fluoro-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]phenyl}methanol

Guidance literature:: methyl 3-[2-ethyl-5-(2-{[3-fluoro-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)-1,3-thiazol-4-yl]benzoate; With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - 50 ℃;

With sodium hydroxide; water; In tetrahydrofuran; methanol;