N-(4-dimethylamino-2-trifluoromethyl-phenyl)-N',N'-bis-(2-methoxy-ethyl)-2-methyl-5-nitro-pyrimidine-4,6-diamine

Base Information

• Chemical Name: N-(4-dimethylamino-2-trifluoromethyl-phenyl)-N',N'-bis-(2-methoxy-ethyl)-2-methyl-5-nitro-pyrimidine-4,6-diamine
• CAS No.: 1028305-20-5
• Molecular Formula: C₂₀H₂₇F₃N₆O₄
• Molecular Weight: 472.467

Synonyms:N-(4-dimethylamino-2-trifluoromethyl-phenyl)-N',N'-bis-(2-methoxy-ethyl)-2-methyl-5-nitro-pyrimidine-4,6-diamine

Chemical Property of N-(4-dimethylamino-2-trifluoromethyl-phenyl)-N',N'-bis-(2-methoxy-ethyl)-2-methyl-5-nitro-pyrimidine-4,6-diamine

Chemical Property:

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Technology Process of N-(4-dimethylamino-2-trifluoromethyl-phenyl)-N',N'-bis-(2-methoxy-ethyl)-2-methyl-5-nitro-pyrimidine-4,6-diamine

There total 4 articles about N-(4-dimethylamino-2-trifluoromethyl-phenyl)-N',N'-bis-(2-methoxy-ethyl)-2-methyl-5-nitro-pyrimidine-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,6-dichloro-2-methyl-5-nitropyrimidine (13162-43-1) → N-(4-dimethylamino-2-trifluoromethyl-phenyl)-N',N'-bis-(2-methoxy-ethyl)-2-methyl-5-nitro-pyrimidine-4,6-diamine (1028305-20-5)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylsulfoxide / Ambient temperature

2: POCl₃ / Heating

3: Et₃N / acetone / Ambient temperature

With triethylamine; trichlorophosphate; In dimethyl sulfoxide; acetone;

DOI:10.1021/jm980224g

Reference yield:

N4,N4-dimethyl-2-trifluoromethyl-benzene-1,4-diamine (73164-30-4) → N-(4-dimethylamino-2-trifluoromethyl-phenyl)-N',N'-bis-(2-methoxy-ethyl)-2-methyl-5-nitro-pyrimidine-4,6-diamine (1028305-20-5)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylsulfoxide / Ambient temperature

2: POCl₃ / Heating

3: Et₃N / acetone / Ambient temperature

With triethylamine; trichlorophosphate; In dimethyl sulfoxide; acetone;

DOI:10.1021/jm980224g

Reference yield:

6-(4-dimethylamino-2-trifluoromethyl-phenylamino)-2-methyl-5-nitro-3H-pyrimidin-4-one (220953-24-2) → N-(4-dimethylamino-2-trifluoromethyl-phenyl)-N',N'-bis-(2-methoxy-ethyl)-2-methyl-5-nitro-pyrimidine-4,6-diamine (1028305-20-5)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃ / Heating

2: Et₃N / acetone / Ambient temperature

With triethylamine; trichlorophosphate; In acetone;

DOI:10.1021/jm980224g

upstream raw materials:

Bis-(2-methoxyethyl)amine

N¹-(6-chloro-2-methyl-5-nitro-pyrimidin-4-yl)-N⁴,N⁴-dimethyl-2-trifluoromethyl-benzene-1,4-diamine

4,6-dichloro-2-methyl-5-nitropyrimidine

N⁴,N⁴-dimethyl-2-trifluoromethyl-benzene-1,4-diamine

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