(R)-{4-{4-chloro-6-[(2,4-dichlorobenzyl)amino]pyrimidin-2-yl}piperazin-1-yl}(piperidin-2-yl)methanone

Base Information

Chemical Name:(R)-{4-{4-chloro-6-[(2,4-dichlorobenzyl)amino]pyrimidin-2-yl}piperazin-1-yl}(piperidin-2-yl)methanone
CAS No.:1448166-21-9
Molecular Formula:C₂₁H₂₅Cl₃N₆O
Molecular Weight:483.828
Hs Code.:

Synonyms:(R)-{4-{4-chloro-6-[(2,4-dichlorobenzyl)amino]pyrimidin-2-yl}piperazin-1-yl}(piperidin-2-yl)methanone

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Chemical Property of (R)-{4-{4-chloro-6-[(2,4-dichlorobenzyl)amino]pyrimidin-2-yl}piperazin-1-yl}(piperidin-2-yl)methanone

Chemical Property:

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Technology Process of (R)-{4-{4-chloro-6-[(2,4-dichlorobenzyl)amino]pyrimidin-2-yl}piperazin-1-yl}(piperidin-2-yl)methanone

There total 5 articles about (R)-{4-{4-chloro-6-[(2,4-dichlorobenzyl)amino]pyrimidin-2-yl}piperazin-1-yl}(piperidin-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₃₃Cl₃N₆O₃

: 1448166-21-9
(R)-{4-{4-chloro-6-[(2,4-dichlorobenzyl)amino]pyrimidin-2-yl}piperazin-1-yl}(piperidin-2-yl)methanone

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 4-(4,6-dichloro-pyrimidin-2-yl)-piperazine-1-carboxylic acid ethyl ester

: 1448166-21-9
(R)-{4-{4-chloro-6-[(2,4-dichlorobenzyl)amino]pyrimidin-2-yl}piperazin-1-yl}(piperidin-2-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 12 h / 90 °C

2: sodium hydroxide; water / ethanol / 24 h / 90 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane;

Reference yield:

: 1723-00-8,83680-83-5
(R)-(+)-pipecolic acid

: 1448166-21-9
(R)-{4-{4-chloro-6-[(2,4-dichlorobenzyl)amino]pyrimidin-2-yl}piperazin-1-yl}(piperidin-2-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / methanol / 24 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;