(R)-3-(((1-Hydroxy-3-phenylpropan-2-yl)aMino)Methyl)-4-nitrobenzonitrile

Base Information

Chemical Name:(R)-3-(((1-Hydroxy-3-phenylpropan-2-yl)aMino)Methyl)-4-nitrobenzonitrile
CAS No.:530145-61-0
Molecular Formula:C₁₇H₁₇N₃O₃
Molecular Weight:311.34
Hs Code.:
Mol file:530145-61-0.mol

Synonyms:(R)-3-[[N-(1-hydroxymethyl-2-phenylethyl)amino]methyl]-4-nitrobenzenecarbonitrile

Suppliers and Price of (R)-3-(((1-Hydroxy-3-phenylpropan-2-yl)aMino)Methyl)-4-nitrobenzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-3-[[N-(1-Hydroxymethyl-2-phenylethyl)amino]methyl]-4-nitrobenzenecarbonitrile
100mg
$ 1320.00

Medical Isotopes, Inc.
(R)-3-[[N-(1-Hydroxymethyl-2-phenylethyl)amino]methyl]-4-nitrobenzenecarbonitrile
100 mg
$ 2200.00

Total 3 raw suppliers

Chemical Property of (R)-3-(((1-Hydroxy-3-phenylpropan-2-yl)aMino)Methyl)-4-nitrobenzonitrile

Chemical Property:

Solubility.:Ethyl Acetate, Dimethylformamide, Dimethyl Sulfoxide, Tetrahydrofuran

Purity/Quality:

99% ^*data from raw suppliers

(R)-3-[[N-(1-Hydroxymethyl-2-phenylethyl)amino]methyl]-4-nitrobenzenecarbonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (R)-3-[[N-(1-Hydroxymethyl-2-phenylethyl)amino]methyl]-4-nitrobenzenecarbonitrile is a reactant used in the preparation of 3,7-disubstituted-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine compounds, having farnesyl protein transferase inhibitory activity.

Technology Process of (R)-3-(((1-Hydroxy-3-phenylpropan-2-yl)aMino)Methyl)-4-nitrobenzonitrile

There total 6 articles about (R)-3-(((1-Hydroxy-3-phenylpropan-2-yl)aMino)Methyl)-4-nitrobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 5267-64-1
(R)-2-amino-3-phenylpropanol

: C₈H₅BrN₂O₂

: 530145-61-0
(R)-3-[[N-(1-hydroxymethyl-2-phenylethyl)amino]methyl]-4-nitrobenzenecarbonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/acs.oprd.8b00307

Reference yield:

: C₁₇H₁₅N₃O₃

: 530145-61-0
(R)-3-[[N-(1-hydroxymethyl-2-phenylethyl)amino]methyl]-4-nitrobenzenecarbonitrile

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 5 - 20 ℃; Reagent/catalyst; Inert atmosphere; Large scale;
DOI:10.1021/acs.oprd.8b00307

Reference yield:

: 96784-54-2
3-methyl-4-nitrobenzonitrile

: 530145-61-0
(R)-3-[[N-(1-hydroxymethyl-2-phenylethyl)amino]methyl]-4-nitrobenzenecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / 7 h / UV-irradiation

2: potassium carbonate / N,N-dimethyl-formamide

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.oprd.8b00307