4-(chlorodiphenylmethyl)-α-phenylbenzeneacetyl chloride

Base Information

• Chemical Name: 4-(chlorodiphenylmethyl)-α-phenylbenzeneacetyl chloride
• CAS No.: 139943-30-9
• Molecular Formula: C₂₇H₂₀Cl₂O
• Molecular Weight: 431.361
• Mol file: 139943-30-9.mol

Synonyms:4-(chlorodiphenylmethyl)-α-phenylbenzeneacetyl chloride

Chemical Property of 4-(chlorodiphenylmethyl)-α-phenylbenzeneacetyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(chlorodiphenylmethyl)-α-phenylbenzeneacetyl chloride

There total 4 articles about 4-(chlorodiphenylmethyl)-α-phenylbenzeneacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylacetic acid (103-82-2) → 4-(chlorodiphenylmethyl)-α-phenylbenzeneacetyl chloride (139943-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) n-BuLi, 2) iodine / 1) THF, hexane, -78 deg C, 1 h, then up to RT, 3 h, 2) -78 deg C up to RT, 18 h

2: 52 percent / conc. sulfuric acid / 0.12 h / 45 °C

3: oxalyl chloride / benzene / 0.7 h / Heating

With n-butyllithium; oxalyl dichloride; sulfuric acid; iodine; In benzene;

DOI:10.1021/jo00036a045

Reference yield:

<4'-(phenylcarboxymethyl)phenyl>diphenylacetic acid (104488-41-7) → 4-(chlorodiphenylmethyl)-α-phenylbenzeneacetyl chloride (139943-30-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / conc. sulfuric acid / 0.12 h / 45 °C

2: oxalyl chloride / benzene / 0.7 h / Heating

With oxalyl dichloride; sulfuric acid; In benzene;

DOI:10.1021/jo00036a045

Reference yield:

<4-<(Methoxycarbonyl)phenylmethyl>phenyl>diphenylessigsaeure-methylester (104488-38-2) → 4-(chlorodiphenylmethyl)-α-phenylbenzeneacetyl chloride (139943-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / 2.5 M aq. NaOH / tetrahydrofuran / 48 h / Heating

2: 52 percent / conc. sulfuric acid / 0.12 h / 45 °C

3: oxalyl chloride / benzene / 0.7 h / Heating

With sodium hydroxide; oxalyl dichloride; sulfuric acid; In tetrahydrofuran; benzene;

DOI:10.1021/jo00036a045

upstream raw materials:

4-(hydroxydiphenylmethyl)-α-phenylbenzeneacetic acid

phenylacetic acid

<4'-(phenylcarboxymethyl)phenyl>diphenylacetic acid

<4-<(Methoxycarbonyl)phenylmethyl>phenyl>diphenylessigsaeure-methylester

Downstream raw materials:

ethyl 4-(hydroxydiphenylmethyl)-α-phenylbenzeneacetate

ethyl 4-(ethoxydiphenylmethyl)-α-phenylbenzeneacetate

methyl 4-(methoxydiphenylmethyl)-α-phenylbenzeneacetate