1-(2-chloroacetyl)indolin-2-one

Base Information

• Chemical Name: 1-(2-chloroacetyl)indolin-2-one
• CAS No.: 937606-68-3
• Molecular Formula: C₁₀H₈ClNO₂
• Molecular Weight: 209.632

Synonyms:1-(2-chloroacetyl)indolin-2-one

Chemical Property of 1-(2-chloroacetyl)indolin-2-one

Chemical Property:

Purity/Quality:

1-(2-CHLOROACETYL)-1,3-DIHYDRO-2H-INDOL-2-ONE 95.00% ^*data from reagent suppliers

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Useful:

• Uses: 1-Chloroacetyloxindole is an intermediate in the synthesis of N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide (D452513), used in the study to discover a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth. N-[4-[[(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)phenylmethyl]amino]phenyl]-N,4-dimethyl-1-piperazineacetamide is an impurity of Intedanib (I666650), which is an antitumor agent.

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