2-[(2-Chloro-4-nitrophenyl)thio]-1-(4-fluorophenyl)ethanone

Base Information

Chemical Name:2-[(2-Chloro-4-nitrophenyl)thio]-1-(4-fluorophenyl)ethanone
CAS No.:203251-38-1
Molecular Formula:C₁₄H₉ClFNO₃S
Molecular Weight:325.748
Hs Code.:
DSSTox Substance ID:DTXSID001190286

Synonyms:DTXSID001190286;2-[(2-Chloro-4-nitrophenyl)thio]-1-(4-fluorophenyl)ethanone;203251-38-1

Suppliers and Price of 2-[(2-Chloro-4-nitrophenyl)thio]-1-(4-fluorophenyl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[(2-Chloro-4-nitrophenyl)thio]-1-(4-fluorophenyl)ethanone

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:324.9975702
Heavy Atom Count:21
Complexity:385

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C(=O)CSC2=C(C=C(C=C2)[N+](=O)[O-])Cl)F

Technology Process of 2-[(2-Chloro-4-nitrophenyl)thio]-1-(4-fluorophenyl)ethanone

There total 1 articles about 2-[(2-Chloro-4-nitrophenyl)thio]-1-(4-fluorophenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 36776-29-1
2-chloro-4-nitro-thiophenol

: 456-04-2
2-Chloro-4'-fluoroacetophenone

: 203251-38-1
2-(2-Chloro-4-nitro-phenylsulfanyl)-1-(4-fluoro-phenyl)-ethanone

Guidance literature:: With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In water; acetone; for 1h; Ambient temperature;
DOI:10.1002/jhet.5570340603

Reference yield: 69.0%

: 203251-38-1
2-(2-Chloro-4-nitro-phenylsulfanyl)-1-(4-fluoro-phenyl)-ethanone

: 183016-10-6
2-(2-Chloro-4-nitro-benzenesulfonyl)-1-(4-fluoro-phenyl)-ethanone

Guidance literature:: With dihydrogen peroxide; In acetic acid; at 55 ℃; for 4.5h;
DOI:10.1002/jhet.5570340603

Reference yield:

: 203251-38-1
2-(2-Chloro-4-nitro-phenylsulfanyl)-1-(4-fluoro-phenyl)-ethanone

: 3-[4-(2-benzoxazolyl)benzyl]-2-(4-fluorophenyl)-7-nitro-1,4-benzoxathiin 4,4-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / 30percent aq. H₂O₂ / acetic acid / 4.5 h / 55 °C

2: 59 percent / K₂CO₃, triethylbenzylammonium chloride / dimethylformamide / 9 h / 60 °C

With N-benzyl-N,N,N-triethylammonium chloride; dihydrogen peroxide; potassium carbonate; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570340603