8-azetidin-1-yl-1-(4-chlorobenzyl)-7-methyl-3-propyl-3,7-dihydro-1H-purine-2,6-dione

Base Information

Chemical Name:8-azetidin-1-yl-1-(4-chlorobenzyl)-7-methyl-3-propyl-3,7-dihydro-1H-purine-2,6-dione
CAS No.:1073238-78-4
Molecular Formula:C₁₉H₂₂ClN₅O₂
Molecular Weight:387.869
Hs Code.:

Synonyms:8-azetidin-1-yl-1-(4-chlorobenzyl)-7-methyl-3-propyl-3,7-dihydro-1H-purine-2,6-dione

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Chemical Property of 8-azetidin-1-yl-1-(4-chlorobenzyl)-7-methyl-3-propyl-3,7-dihydro-1H-purine-2,6-dione

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Technology Process of 8-azetidin-1-yl-1-(4-chlorobenzyl)-7-methyl-3-propyl-3,7-dihydro-1H-purine-2,6-dione

There total 7 articles about 8-azetidin-1-yl-1-(4-chlorobenzyl)-7-methyl-3-propyl-3,7-dihydro-1H-purine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 503-29-7
azetidine

: 1073238-90-0
8-bromo-1-(4-chlorobenzyl)-7-methyl-3-propyl-3,7-dihydro-1H-purine-2,6-dione

: 1073238-78-4
8-azetidin-1-yl-1-(4-chlorobenzyl)-7-methyl-3-propyl-3,7-dihydro-1H-purine-2,6-dione

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethanol; at 120 ℃; for 1h; Microwaves;

Reference yield:

: 896420-11-4
1-(4-chlorobenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione

: 1073238-78-4
8-azetidin-1-yl-1-(4-chlorobenzyl)-7-methyl-3-propyl-3,7-dihydro-1H-purine-2,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1: bromine; potassium acetate / acetic acid / 45 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: N-ethyl-N,N-diisopropylamine / ethanol / 1 h / 120 °C / Microwaves

With bromine; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 53681-47-3
6-amino-1-propyl-1H-pyrimidine-2,4-dione

: 1073238-78-4
8-azetidin-1-yl-1-(4-chlorobenzyl)-7-methyl-3-propyl-3,7-dihydro-1H-purine-2,6-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide dimethyl acetal / N,N-dimethyl-formamide / 3.5 h / 40 °C

1.2: 73 h / 40 - 80 °C

1.3: 1 h / 120 °C / Microwaves

2.1: acetic acid; sodium nitrite / water / 1 h / 80 °C

3.1: sodium dithionite; ammonia / water; acetonitrile / 1.08 h / 80 °C

4.1: 1.5 h / 120 °C

5.1: bromine; potassium acetate / acetic acid / 45 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / ethanol / 1 h / 120 °C / Microwaves

With sodium dithionite; ammonia; bromine; potassium acetate; potassium carbonate; acetic acid; N,N-dimethyl-formamide dimethyl acetal; N-ethyl-N,N-diisopropylamine; sodium nitrite; In ethanol; water; acetic acid; N,N-dimethyl-formamide; acetonitrile;