2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-oxo-pentanoic acid methyl ester

Base Information

Chemical Name:2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-oxo-pentanoic acid methyl ester
CAS No.:182866-66-6
Molecular Formula:C₁₉H₂₆N₂O₆
Molecular Weight:378.425
Hs Code.:

Synonyms:2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-oxo-pentanoic acid methyl ester

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Chemical Property of 2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-oxo-pentanoic acid methyl ester

Chemical Property:

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Technology Process of 2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-oxo-pentanoic acid methyl ester

There total 4 articles about 2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-oxo-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 13139-28-1
(S)-N-benzyloxycarbonylvalinamide

: 104034-82-4
methyl 2-diazo-3-oxo-pentanoate

: 182866-66-6
2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-oxo-pentanoic acid methyl ester

Guidance literature:: dirhodium tetraacetate; In chloroform; for 0.5h; Heating;
DOI:10.1039/a704093h

Reference yield:

: 30414-53-0
methyl propanoyl acetate

: 182866-66-6
2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-oxo-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 4-acetamidobenzenesulfonyl azide, Et₃N / acetonitrile / 16 h / Ambient temperature

2: 48 percent / Rh₂(OAc)4 / CHCl₃ / 0.5 h / Heating

With 4-acetamidobenzenesulfonyl azide; triethylamine; dirhodium tetraacetate; In chloroform; acetonitrile;
DOI:10.1039/a704093h

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 182866-66-6
2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-oxo-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 0.5 h / 0 °C

2: aq. NH₃ / tetrahydrofuran / 0.5 h / 0 °C

3: 48 percent / Rh₂(OAc)4 / CHCl₃ / 0.5 h / Heating

With ammonium hydroxide; triethylamine; dirhodium tetraacetate; In tetrahydrofuran; chloroform;
DOI:10.1039/a704093h